دورية أكاديمية
Smooth muscle hyperplasia in protein kinase C-fused blue naevi: Report of 12 cases.
| العنوان: | Smooth muscle hyperplasia in protein kinase C-fused blue naevi: Report of 12 cases. |
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| المؤلفون: | Goutas D; First Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, Athens, Greece., Hayenne P; Centre Léon Bérard, Cancer Research Center of Lyon, Equipe Labellisée Ligue contre le Cancer, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Tirode F; Centre Léon Bérard, Cancer Research Center of Lyon, Equipe Labellisée Ligue contre le Cancer, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Pissaloux D; Centre Léon Bérard, Cancer Research Center of Lyon, Equipe Labellisée Ligue contre le Cancer, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Yeh I; Department of Dermatology, University of California, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, CA, USA., de la Fouchardiere A; Centre Léon Bérard, Cancer Research Center of Lyon, Equipe Labellisée Ligue contre le Cancer, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France. |
| المصدر: | Histopathology [Histopathology] 2024 Aug; Vol. 85 (2), pp. 347-352. Date of Electronic Publication: 2024 May 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Hyperplasia*/pathology , Protein Kinase C*/genetics , Protein Kinase C*/metabolism , Skin Neoplasms*/pathology , Skin Neoplasms*/genetics , Nevus, Blue*/pathology , Nevus, Blue*/genetics , Nevus, Blue*/diagnosis , Muscle, Smooth*/pathology, Humans ; Female ; Male ; Adult ; Middle Aged ; Adolescent ; Young Adult ; Child ; Aged |
| مستخلص: | Background and Aims: PKC-fused blue naevi are a recently described group of melanocytic tumours that have distinctive morphological features, including a pigmented epithelioid melanocytoma-like junctional component or a dermal biphasic architecture associating with naevocytoid nests surrounded by dendritic and spindled pigmented melanocytes (so-called 'combined common and blue naevus'). There have been reports of smooth muscle hyperplasia in a hamartoma-like pattern in cases of combined blue naevi without genetic exploration. Materials and Methods: Herein, we describe 12 cases of protein kinase C (PKC)-fused blue tumours associated with a co-existing smooth muscle hyperplasia, identified from a total of 98 PKC-fused melanocytic tumours. Archived slides of PKC-fused blue naevi with haematoxylin, eosin and phloxin staining, immunohistochemistry and molecular confirmation of a PKC-fusion by fluorescence in-situ hybridisation (FISH) or RNAseq were re-evaluated for identification of notable smooth muscle hyperplasia. Fifty-one of these slides had already been studied in a previous publication from our group. Results: The hyperplasia ranged from hypertrophic arrector pili muscles to extensive horizontal bundles of disorganised fibres constantly associated and limited within a biphasic dermal melanocytic component. At least one arrector pili muscle was always visible within the tumour, with occasionally direct extension of the hyperplastic fibres from the main muscle body. These muscle fibres were devoid of a PKC-fusion signal by FISH. PKC molecules are involved in the regulation of smooth muscle function, offering an explanatory framework. Conclusions: These data suggest incorporating smooth muscle hyperplasia as a diagnostic morphological feature of PKC-fused blue melanocytic tumours. (© 2024 John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: PKC‐fused; blue naevus; hamartoma; smooth muscle hyperplasia |
| المشرفين على المادة: | EC 2.7.11.13 (Protein Kinase C) |
| تواريخ الأحداث: | Date Created: 20240515 Date Completed: 20240714 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1111/his.15211 |
| PMID: | 38747196 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2559 |
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| DOI: | 10.1111/his.15211 |