دورية أكاديمية
أعرض في EDS

Deciphering the chemical language of inbred and wild mouse conspecific scents.

التفاصيل البيبلوغرافية
العنوان: Deciphering the chemical language of inbred and wild mouse conspecific scents.
المؤلفون: Nagel M; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Niestroj M; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Bansal R; Department of Medical Neurobiology, Institute for Medical Research Israel Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Fleck D; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Lampert A; Institute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany.; Research Training Group 2416 MultiSenses - MultiScales, RWTH Aachen University, Aachen, Germany., Stopkova R; BIOCEV group, Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic., Stopka P; BIOCEV group, Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic., Ben-Shaul Y; Department of Medical Neurobiology, Institute for Medical Research Israel Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Spehr M; Department of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany.; Research Training Group 2416 MultiSenses - MultiScales, RWTH Aachen University, Aachen, Germany.
المصدر: ELife [Elife] 2024 May 15; Vol. 12. Date of Electronic Publication: 2024 May 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Vomeronasal Organ*/physiology, Animals ; Mice ; Male ; Female ; Odorants/analysis ; Pheromones/urine ; Pheromones/metabolism ; Mice, Inbred C57BL ; Mice, Inbred Strains
مستخلص: In most mammals, conspecific chemosensory communication relies on semiochemical release within complex bodily secretions and subsequent stimulus detection by the vomeronasal organ (VNO). Urine, a rich source of ethologically relevant chemosignals, conveys detailed information about sex, social hierarchy, health, and reproductive state, which becomes accessible to a conspecific via vomeronasal sampling. So far, however, numerous aspects of social chemosignaling along the vomeronasal pathway remain unclear. Moreover, since virtually all research on vomeronasal physiology is based on secretions derived from inbred laboratory mice, it remains uncertain whether such stimuli provide a true representation of potentially more relevant cues found in the wild. Here, we combine a robust low-noise VNO activity assay with comparative molecular profiling of sex- and strain-specific mouse urine samples from two inbred laboratory strains as well as from wild mice. With comprehensive molecular portraits of these secretions, VNO activity analysis now enables us to (i) assess whether and, if so, how much sex/strain-selective 'raw' chemical information in urine is accessible via vomeronasal sampling; (ii) identify which chemicals exhibit sufficient discriminatory power to signal an animal's sex, strain, or both; (iii) determine the extent to which wild mouse secretions are unique; and (iv) analyze whether vomeronasal response profiles differ between strains. We report both sex- and, in particular, strain-selective VNO representations of chemical information. Within the urinary 'secretome', both volatile compounds and proteins exhibit sufficient discriminative power to provide sex- and strain-specific molecular fingerprints. While total protein amount is substantially enriched in male urine, females secrete a larger variety at overall comparatively low concentrations. Surprisingly, the molecular spectrum of wild mouse urine does not dramatically exceed that of inbred strains. Finally, vomeronasal response profiles differ between C57BL/6 and BALB/c animals, with particularly disparate representations of female semiochemicals.
Competing Interests: MN, MN, RB, DF, AL, RS, PS, YB, MS No competing interests declared
(© 2023, Nagel et al.)
References: Science. 2008 Apr 25;320(5875):535-8. (PMID: 18436787)
Nat Genet. 2005 Nov;37(11):1175-80. (PMID: 16254563)
Chem Senses. 2012 Nov;37(9):849-58. (PMID: 22923146)
Nat Rev Drug Discov. 2008 Jun;7(6):489-503. (PMID: 18511927)
J Biol Chem. 1969 Nov 25;244(22):6049-55. (PMID: 5389100)
Cell. 2015 Jun 4;161(6):1334-44. (PMID: 26046438)
J Immunol. 2021 May 1;206(9):2109-2121. (PMID: 33858960)
Nature. 2020 Feb;578(7793):137-141. (PMID: 31996852)
Nat Commun. 2013;4:1616. (PMID: 23511480)
Cell. 2015 Oct 8;163(2):313-23. (PMID: 26435105)
BMC Bioinformatics. 2011 Jun 22;12:253. (PMID: 21693065)
Cell. 2014 Apr 24;157(3):676-88. (PMID: 24766811)
Nature. 2006 Nov 16;444(7117):308-15. (PMID: 17108955)
Nature. 2001 Dec 6;414(6864):631-4. (PMID: 11740558)
Front Neuroanat. 2012 Nov 09;6:46. (PMID: 23162438)
J Neurosci. 2012 Feb 1;32(5):1612-21. (PMID: 22302803)
Nat Rev Neurosci. 2003 Jul;4(7):551-62. (PMID: 12838330)
BMC Biol. 2021 Jun 28;19(1):133. (PMID: 34182994)
J Neurosci. 2008 Jun 18;28(25):6407-18. (PMID: 18562612)
Anim Behav. 1998 May;55(5):1289-97. (PMID: 9632512)
Neuron. 2016 Aug 17;91(4):878-892. (PMID: 27537487)
Physiol Rev. 2009 Jul;89(3):921-56. (PMID: 19584317)
Nature. 2000 Jun 15;405(6788):792-6. (PMID: 10866200)
Curr Biol. 2017 Aug 7;27(15):R739-R743. (PMID: 28787598)
J Neurosci. 2010 Jun 2;30(22):7473-83. (PMID: 20519522)
Science. 2003 Feb 21;299(5610):1196-201. (PMID: 12595684)
Chem Senses. 2018 Nov 1;43(9):667-695. (PMID: 30256909)
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4634-8. (PMID: 2660142)
Biochem Soc Trans. 2003 Feb;31(Pt 1):117-22. (PMID: 12546667)
Science. 2004 Nov 5;306(5698):1033-7. (PMID: 15528444)
eNeuro. 2018 Aug 13;5(4):. (PMID: 30105301)
J Proteome Res. 2008 Jan;7(1):300-5. (PMID: 18067249)
J Chem Ecol. 2002 Jul;28(7):1429-46. (PMID: 12199505)
Nature. 2011 Sep 21;478(7368):241-5. (PMID: 21937988)
Sci Rep. 2021 Mar 5;11(1):5312. (PMID: 33674647)
Genomics. 1995 Apr 10;26(3):535-42. (PMID: 7607677)
Science. 2012 Dec 14;338(6113):1462-5. (PMID: 23239735)
BMC Bioinformatics. 2004 Dec 17;5:203. (PMID: 15606915)
BMC Evol Biol. 2020 Aug 8;20(1):99. (PMID: 32770934)
Cell Mol Life Sci. 2014 Jul;71(13):2429-42. (PMID: 24496643)
BMC Biol. 2010 Jun 03;8:75. (PMID: 20525243)
Nature. 1995 Aug 31;376(6543):737-45. (PMID: 7544443)
Annu Rev Neurosci. 2014;37:363-85. (PMID: 24905594)
BMC Genomics. 2012 Aug 21;13:415. (PMID: 22908939)
Nature. 2009 May 28;459(7246):574-7. (PMID: 19387439)
Sci Rep. 2023 May 26;13(1):8573. (PMID: 37237091)
PLoS Comput Biol. 2017 Nov 3;13(11):e1005752. (PMID: 29099853)
Physiol Behav. 2009 Feb 16;96(2):253-61. (PMID: 18973768)
Front Physiol. 2021 Sep 14;12:740006. (PMID: 34594242)
Elife. 2017 Apr 25;6:. (PMID: 28438259)
PLoS Comput Biol. 2016 Mar 03;12(3):e1004798. (PMID: 26938460)
Sci Rep. 2017 Sep 15;7(1):11674. (PMID: 28916783)
IEEE Trans Image Process. 1998;7(1):27-41. (PMID: 18267377)
Mol Ecol. 2011 Dec;20(24):5248-64. (PMID: 22066696)
Elife. 2014 Jul 29;3:e03025. (PMID: 25073926)
Nucleic Acids Res. 2012 Sep 1;40(17):8733-42. (PMID: 22735700)
Nature. 2007 Dec 6;450(7171):899-902. (PMID: 18064011)
Anal Chim Acta. 2015 Jun 16;879:10-23. (PMID: 26002472)
Nat Neurosci. 2012 Mar 25;15(5):754-62. (PMID: 22446879)
Front Neurosci. 2015 Nov 20;9:439. (PMID: 26635515)
Nat Genet. 2018 Nov;50(11):1574-1583. (PMID: 30275530)
J Neurosci. 2015 Mar 4;35(9):4025-39. (PMID: 25740530)
Brain Res. 1980 Mar 3;185(1):103-13. (PMID: 7353170)
Mol Cell Proteomics. 2014 Sep;13(9):2513-26. (PMID: 24942700)
Elife. 2015 Apr 15;4:. (PMID: 25875302)
Curr Biol. 2024 Mar 25;34(6):1206-1221.e6. (PMID: 38320553)
J Physiol. 2011 Nov 1;589(Pt 21):5033-55. (PMID: 21859825)
PeerJ. 2017 Jul 7;5:e3541. (PMID: 28698824)
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. (PMID: 34723319)
Neuron. 2017 Jul 5;95(1):123-137.e8. (PMID: 28648498)
Front Neurosci. 2015 Jul 14;9:244. (PMID: 26236183)
J Neurosci. 2009 Jan 7;29(1):206-21. (PMID: 19129398)
Genome Biol Evol. 2011;3:401-12. (PMID: 21551350)
Nat Commun. 2016 Jun 21;7:11936. (PMID: 27324439)
BMC Genomics. 2017 Dec 12;18(1):965. (PMID: 29233099)
J Chem Ecol. 2006 Jun;32(6):1333-46. (PMID: 16770722)
Nature. 2005 Oct 6;437(7060):898-901. (PMID: 16208374)
FASEB J. 1991 Mar 1;5(3):301-8. (PMID: 2001789)
معلومات مُعتمدة: 368482240/GRK2416 Deutsche Forschungsgemeinschaft; 378028035 Deutsche Forschungsgemeinschaft; I/83533 Volkswagen Foundation; 1-1193-153.13/2012 German-Israeli Foundation for Scientific Research and Development
فهرسة مساهمة: Keywords: biochemistry; chemical biology; chemosensory system; chemosignaling; mouse; neuroscience; olfaction; vomeronasal organ; vomeronasal sensory neurons
تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240515 Latest Revision: 20240517
رمز التحديث: 20240517
مُعرف محوري في PubMed: PMC11095937
DOI: 10.7554/eLife.90529
PMID: 38747258
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.90529