دورية أكاديمية
Comparison of Corneal Biomechanical Efficacy Between Rose Bengal-Green Light and Riboflavin-UVA Crosslinking.
| العنوان: | Comparison of Corneal Biomechanical Efficacy Between Rose Bengal-Green Light and Riboflavin-UVA Crosslinking. |
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| المؤلفون: | Yesilirmak N; Department of Ophthalmology, Ankara Yildirim Beyazit University, Ankara, Turkey.; Department of Biochemistry, Gazi University, Ankara, Turkey., Saritas O; Department of Ophthalmology, Battalgazi Public Hospital, Malatya, Turkey. |
| المصدر: | Current eye research [Curr Eye Res] 2024 Sep; Vol. 49 (9), pp. 942-948. Date of Electronic Publication: 2024 May 15. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8104312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2202 (Electronic) Linking ISSN: 02713683 NLM ISO Abbreviation: Curr Eye Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : IRL Press, [c1981- |
| مواضيع طبية MeSH: | Cornea*/drug effects , Cornea*/physiopathology , Elasticity*/drug effects , Elasticity*/physiology , Elasticity*/radiation effects , Photochemotherapy*/methods , Photosensitizing Agents*/therapeutic use , Photosensitizing Agents*/pharmacology , Riboflavin*/therapeutic use , Rose Bengal*/pharmacology , Ultraviolet Rays*, Animals ; Biomechanical Phenomena ; Collagen/metabolism ; Cross-Linking Reagents ; Disease Models, Animal ; Elastic Modulus ; Fluorescent Dyes ; Green Light ; Keratoconus/drug therapy ; Keratoconus/physiopathology ; Sheep |
| مستخلص: | Purpose: To investigate corneal biomechanical changes after corneal cross-linking (CXL) treatments with rose bengal-green light (RB-CXL) and riboflavin-UVA (RF-CXL). Methods: A total of 60 freshly enucleated lamb eyes were obtained for this experimental study. Fifteen eyes were treated with RB-CXL using 0.1% RB solution (Group 1), 15 eyes were treated with RB-CXL using 0.2% RB solution (Group 2), 15 eyes were treated with RF-CXL using 0.1% RF solution (Group 3), and 15 eyes were used as controls (Group 4). The same treatment protocol (10-minute irradiation using a total of 5.4 J/cm 2 energy) was applied to all treatment groups. To evaluate corneal biomechanical changes, the stress-strain test was used for both the treated and control corneas. The elastic modulus was calculated using the tension strain curves obtained during the test. Results: The average elastic modulus values were calculated to be 18.9, 23.5, 22.3, and 14.1 MPa in Groups 1, 2, 3, and 4, respectively. Statistically significant differences were found between the groups ( p < 0.001 for Group 1 vs. 2; p < 0.001 for Group 1 vs. 3; p < 0.001 for Group 1 vs. 4; p = 0.002 for Group 2 vs. 3; p < 0.001 for Group 2 vs. 4; and p < 0.001 for Group 3 vs. 4). Conclusions: In this study, the efficacy of RB-CXL treatment applied using different concentrations of RB solutions at a total energy of 5.4 J/cm 2 was investigated, and 0.2% RB solution was found to have at least as much and even more effective than the RF-CXL (0.1% RF) on the corneal elasticity module. These results are encouraging for the treatment of ectatic corneas particularly below 400 μm. It is considered that the findings obtained from this study will guide future experimental and clinical studies. |
| فهرسة مساهمة: | Keywords: Rose bengal; cornea; crosslinking; green light |
| المشرفين على المادة: | 9007-34-5 (Collagen) 0 (Cross-Linking Reagents) 0 (Fluorescent Dyes) 0 (Photosensitizing Agents) TLM2976OFR (Riboflavin) 1ZPG1ELY14 (Rose Bengal) |
| تواريخ الأحداث: | Date Created: 20240515 Date Completed: 20240809 Latest Revision: 20240809 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1080/02713683.2024.2353267 |
| PMID: | 38747449 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1460-2202 |
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| DOI: | 10.1080/02713683.2024.2353267 |