دورية أكاديمية
أعرض في EDS

Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients.

التفاصيل البيبلوغرافية
العنوان: Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients.
المؤلفون: Medeiros W; Microbial Resources Division, Research Center for Chemistry, Biology, and Agriculture (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia, São Paulo, Brazil.; Interfaculty Institute of Microbiology, and Infection Medicine Institute for Bioinformatics and Medical Informatics, German Centre for Infection Research (DZIF), Tübingen, Germany., Hidalgo K; Microbial Resources Division, Research Center for Chemistry, Biology, and Agriculture (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia, São Paulo, Brazil., Leão T; Chemistry Institute, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., de Carvalho LM; Center for Computing in Engineering and Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil., Ziemert N; Interfaculty Institute of Microbiology, and Infection Medicine Institute for Bioinformatics and Medical Informatics, German Centre for Infection Research (DZIF), Tübingen, Germany., Oliveira V; Microbial Resources Division, Research Center for Chemistry, Biology, and Agriculture (CPQBA), Universidade Estadual de Campinas (UNICAMP), Paulínia, São Paulo, Brazil.
المصدر: Microbiology spectrum [Microbiol Spectr] 2024 Jun 04; Vol. 12 (6), pp. e0024424. Date of Electronic Publication: 2024 May 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : ASM Press, 2013-
مواضيع طبية MeSH: Microbiota*/genetics , Metagenome*, Antarctic Regions ; Bacteria/genetics ; Bacteria/classification ; Bacteria/metabolism ; Multigene Family ; Biofilms ; Phylogeny ; Proteobacteria/genetics ; Proteobacteria/metabolism ; Proteobacteria/classification ; Terpenes/metabolism ; Bacteroidetes/genetics ; Bacteroidetes/metabolism ; Bacteroidetes/classification
مستخلص: Extreme environments, such as Antarctica, select microbial communities that display a range of evolutionary strategies to survive and thrive under harsh environmental conditions. These include a diversity of specialized metabolites, which have the potential to be a source for new natural product discovery. Efforts using (meta)genome mining approaches to identify and understand biosynthetic gene clusters in Antarctica are still scarce, and the extent of their diversity and distribution patterns in the environment have yet to be discovered. Herein, we investigated the biosynthetic gene diversity of the biofilm microbial community of Whalers Bay, Deception Island, in the Antarctic Peninsula and revealed its distribution patterns along spatial and temporal gradients by applying metagenome mining approaches and multivariable analysis. The results showed that the Whalers Bay microbial community harbors a great diversity of biosynthetic gene clusters distributed into seven classes, with terpene being the most abundant. The phyla Proteobacteria and Bacteroidota were the most abundant in the microbial community and contributed significantly to the biosynthetic gene abundances in Whalers Bay. Furthermore, the results highlighted a significant correlation between the distribution of biosynthetic genes and taxonomic diversity, emphasizing the intricate interplay between microbial taxonomy and their potential for specialized metabolite production.IMPORTANCEThis research on antarctic microbial biosynthetic diversity in Whalers Bay, Deception Island, unveils the hidden potential of extreme environments for natural product discovery. By employing metagenomic techniques, the research highlights the extensive diversity of biosynthetic gene clusters and identifies key microbial phyla, Proteobacteria and Bacteroidota, as significant contributors. The correlation between taxonomic diversity and biosynthetic gene distribution underscores the intricate interplay governing specialized metabolite production. These findings are crucial for understanding microbial adaptation in extreme environments and hold significant implications for bioprospecting initiatives. The study opens avenues for discovering novel bioactive compounds with potential applications in medicine and industry, emphasizing the importance of preserving and exploring these polyextreme ecosystems to advance biotechnological and pharmaceutical research.
Competing Interests: The authors declare no conflicts of interest.
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معلومات مُعتمدة: 2020/11534-0, 2022/15112-8 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); 2019/12914-3 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
فهرسة مساهمة: Keywords: Antarctic environments; Whalers Bay; biosynthetic gene clusters; metagenome mining
المشرفين على المادة: 0 (Terpenes)
تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240605 Latest Revision: 20240807
رمز التحديث: 20240807
مُعرف محوري في PubMed: PMC11237469
DOI: 10.1128/spectrum.00244-24
PMID: 38747631
قاعدة البيانات: MEDLINE
الوصف
تدمد:2165-0497
DOI:10.1128/spectrum.00244-24