دورية أكاديمية
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Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.

التفاصيل البيبلوغرافية
العنوان: Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.
عنوان ترانسليتريتد: Efeitos da Suplementação de Vitamina D sobre Parâmetros Hemodinâmicos Centrais e Sistema Nervoso Autônomo em Indivíduos com Obesidade ou Sobrepeso.
المؤلفون: Faria ACC; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Moreira CL; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Cunha MRD; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.; Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Mattos S; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Oigman W; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Neves MF; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
المصدر: Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2024 Apr; Vol. 121 (5), pp. e20230678.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: Portuguese; English
بيانات الدورية: Publisher: Sociedad Brasileira De Cardiologia Country of Publication: Brazil NLM ID: 0421031 Publication Model: Print Cited Medium: Internet ISSN: 1678-4170 (Electronic) Linking ISSN: 0066782X NLM ISO Abbreviation: Arq Bras Cardiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Sao Paulo : Sociedad Brasileira De Cardiologia
مواضيع طبية MeSH: Autonomic Nervous System*/drug effects , Autonomic Nervous System*/physiopathology , Hemodynamics*/drug effects , Dietary Supplements* , Obesity*/physiopathology , Obesity*/complications , Heart Rate*/drug effects , Heart Rate*/physiology , Cholecalciferol*/administration & dosage , Overweight*/physiopathology , Overweight*/complications , Vitamin D*/blood, Humans ; Middle Aged ; Male ; Female ; Double-Blind Method ; Adult ; Prospective Studies ; Aged ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Treatment Outcome ; Vitamin D Deficiency/physiopathology ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/complications ; Body Mass Index ; Vitamins/administration & dosage ; Vitamins/therapeutic use ; Time Factors ; Reference Values ; Statistics, Nonparametric
مستخلص: Background: Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation.
Objective: To evaluate the effects of vitamin D3 supplementation on central hemodynamic parameters and autonomic activity in obese/overweight individuals with low vitamin D levels (<30ng/dl).
Methods: Adults 40-65 years old with body mass index ≥25<40 kg/m2 were enrolled in this prospective, randomized, double-blind clinical trial (NCT05689632). Central hemodynamics was assessed using the oscillometric method (Mobil-O-Graph®), and heart rate variability using a Polar heart rate monitor (Kubios® software). Patients (n=53) received a placebo in the control group (CO, n=25) or vitamin D3 (VD, n=28) 7000 IU/day, and were evaluated before (W0) and after 8 weeks (W8) with a significance level of 0.05.
Results: The groups were homogeneous regarding age (51±6 vs 52±6 years, p=0.509) and vitamin D levels (22.8±4.9 vs 21.7±4.5ng/ml, p=0.590). At W8, the VD group had significantly higher levels of vitamin D (22.5 vs 35.6ng/ml, p<0.001). Only the VD group showed a significant reduction in systolic blood pressure (SBP; 123±15 vs 119±14mmHg, p=0.019) and alkaline phosphatase (213±55 vs 202±55mg/dl, p=0.012). The CO group showed an increase in augmentation pressure (AP: 9 vs 12 mmHg, p=0.028) and augmentation index (AIx: 26 vs 35%, p=0.020), which was not observed in the VD group (AP: 8 vs 8 mmHg, AIx: 26 vs 25%, p>0.05). VD group showed an increase in the parasympathetic nervous system index (PNSi) (-0.64±0.94 vs -0.16±1.10, p=0.028) and the R-R interval (866±138 vs 924±161 ms, p= 0.026).
Conclusion: In this sample, eight weeks of daily vitamin D supplementation resulted in an improvement in blood pressure levels and autonomic balance.
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فهرسة مساهمة: Local Abstract: [Publisher, Portuguese] Estudos prévios têm sido inconsistentes em demonstrar efeitos cardiovasculares benéficos da suplementação de vitamina D. [Publisher, Portuguese] Avaliar efeitos da suplementação de vitamina D3 sobre parâmetros hemodinâmicos centrais e atividade autonômica em indivíduos obesos/sobrepeso e baixos níveis de vitamina D (<30ng/dl). [Publisher, Portuguese] Ensaio clínico prospectivo, randomizado, duplo-cego (NCT05689632), adultos 40-65 anos com índice de massa corporal ≥25<40 kg/m2. Hemodinâmica central avaliada por método oscilométrico (Mobil-O-Graph®), variabilidade da frequência cardíaca utilizando frequencímetro Polar (software Kubios®). Os pacientes (n=53) receberam placebo no grupo controle (CO, n=25) ou vitamina D3 (VD, n=28) 7000 UI/dia, avaliados antes (S0) e após 8 semanas (S8) com nível de significância de 0,05. [Publisher, Portuguese] Os grupos foram homogêneos na idade (51±6 vs. 52±6 anos, p=0,509) e níveis de vitamina D (22,8±4,9 vs. 21,7±4,5ng/ml, p=0,590). Na S8, o grupo VD apresentou níveis significativamente maiores de vitamina D (22,5 vs. 35,6ng/ml, p<0,001). Apenas o grupo VD mostrou redução significativa da pressão arterial sistólica (PAS; 123±15 vs. 119±14mmHg, p=0,019) e fosfatase alcalina (213±55 vs. 202±55mg/dl, p=0,012). O grupo CO mostrou elevação da pressão de aumento (AP: 9 vs. 12mmHg, p=0,028) e do índice de incremento (Aix: 26 vs. 35%, p=0,020), o que não foi observado no grupo VD (AP: 8 vs. 8mmHg, Aix: 26 vs. 25%, p>0,05). Grupo VD apresentou aumento no índice do sistema nervoso (iSN) parassimpático (-0,64±0,94 vs. -0,16±1,10, p=0,028) e no intervalo R-R (866±138 vs. 924±161ms, p=0,026). [Publisher, Portuguese] Nesta amostra, a suplementação diária de vitamina D durante oito semanas resultou em melhora dos níveis pressóricos, parâmetros hemodinâmicos centrais e do equilíbrio autonômico.
تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240515 Latest Revision: 20240613
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC11098585
DOI: 10.36660/abc.20230678
PMID: 38747749
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4170
DOI:10.36660/abc.20230678