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SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient.

التفاصيل البيبلوغرافية
العنوان: SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient.
المؤلفون: Mendes-Correa MC; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Ghilardi FR; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil., Salomão MC; Hospital 9 de Julho, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, São Paulo, São Paulo, Brazil., Villas-Boas LS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Paula AV; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Paiao HGO; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Costa ACD; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Tozetto-Mendoza TR; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Freire W; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil., Sales FCS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil., Claro IM; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil., Sabino EC; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil., Faria NR; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.; Imperial College, Department of Infectious Disease Epidemiology, London, United Kindgom.; University of Oxford, Department of Zoology, Oxford, United Kindgom., Witkin SS; Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.; Weill Cornell Medicine, Department of Obstetrics and Gynecology, New York, New York, USA.
المصدر: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2024 May 13; Vol. 66, pp. e28. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9946 (Electronic) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo
مواضيع طبية MeSH: COVID-19*/immunology , SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , Immunocompromised Host* , Virus Shedding*, Humans ; Adult ; Male ; Lymphoma, Large B-Cell, Diffuse/virology ; Lymphoma, Large B-Cell, Diffuse/immunology ; Hematopoietic Stem Cell Transplantation ; Whole Genome Sequencing
مستخلص: This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset.
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تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240515 Latest Revision: 20240518
رمز التحديث: 20240518
مُعرف محوري في PubMed: PMC11095242
DOI: 10.1590/S1678-9946202466028
PMID: 38747849
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-9946
DOI:10.1590/S1678-9946202466028