دورية أكاديمية

Newly synthesized surfactants as antimicrobial and anti-adhesion agents.

التفاصيل البيبلوغرافية
العنوان: Newly synthesized surfactants as antimicrobial and anti-adhesion agents.
المؤلفون: Izbińska P; Department of Physicochemistry of Microorganisms, Faculty of Biological Sciences, University of Wrocław, Przybyszewskiego 63/77, Wrocław 51-148, Poland., Lamch Ł; Department of Engineering and Technology of Chemical Processes, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland., Szlauer W; Department of Physicochemistry of Microorganisms, Faculty of Biological Sciences, University of Wrocław, Przybyszewskiego 63/77, Wrocław 51-148, Poland., Wilk KA; Department of Engineering and Technology of Chemical Processes, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland., Obłąk E; Department of Physicochemistry of Microorganisms, Faculty of Biological Sciences, University of Wrocław, Przybyszewskiego 63/77, Wrocław 51-148, Poland. Electronic address: ewa.oblak@uwr.edu.pl.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jul; Vol. 239, pp. 113932. Date of Electronic Publication: 2024 May 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Surface-Active Agents*/pharmacology , Surface-Active Agents*/chemistry , Surface-Active Agents*/chemical synthesis , Microbial Sensitivity Tests* , Candida albicans*/drug effects , Hemolysis*/drug effects, Sheep ; Animals ; Erythrocytes/drug effects ; Biofilms/drug effects ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Quaternary Ammonium Compounds/chemistry ; Quaternary Ammonium Compounds/pharmacology ; Quaternary Ammonium Compounds/chemical synthesis ; Antifungal Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry
مستخلص: Quaternary ammonium salts (QAS) are widely used in medicine, industry and agriculture as disinfectants, biocides, and fungicides. QAS have the ability to coat various surfaces, prevent adhesion of microorganisms to them and inhibit the formation of biofilm. A group of surfactants derived from benzoic acid with different chemical structures was tested: monomeric QAS with different alkyl chain lengths (C 12 , C 14 , C 16 ), gemini QAS containing 12-carbon alkyl chains and linkers of various lengths (3,4,6 methylene groups), as well as multifunctional QAS. Among the tested surfactants, monomeric QAS showed the highest bactericidal and fungicidal activity. All three groups of tested compounds inhibited the filamentation of C. albicans. The best antimicrobial activity was demonstrated by the monomeric surfactant C 12 AA, while the multifunctional equivalent (2xC 12 AA) was characterized by good anti-adhesive activity. All tested compounds are non-mutagenic and cause low hemolysis of sheep erythrocytes. Multifunctional and gemini surfactants are also non-toxic.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Adhesion; Biofilm; Filamentation; Gemini quaternary ammonium salts (QAS); Haemolysis; Monomeric QAS
المشرفين على المادة: 0 (Surface-Active Agents)
0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
0 (Quaternary Ammonium Compounds)
0 (Antifungal Agents)
تواريخ الأحداث: Date Created: 20240515 Date Completed: 20240606 Latest Revision: 20240606
رمز التحديث: 20240607
DOI: 10.1016/j.colsurfb.2024.113932
PMID: 38749165
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2024.113932