دورية أكاديمية
Recommendations for reporting tissue and circulating tumour (ct)DNA next-generation sequencing results in non-small cell lung cancer.
العنوان: | Recommendations for reporting tissue and circulating tumour (ct)DNA next-generation sequencing results in non-small cell lung cancer. |
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المؤلفون: | Malapelle U; Department of Public Health, University of Naples Federico II, Naples, Italy., Leighl N; Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Addeo A; Oncology Unit, Geneva University Hospital, Geneva, Switzerland., Hershkovitz D; Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel., Hochmair MJ; Department of Respiratory & Critical Care Medicine, Karl Landsteiner Institute of Lung Research & Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria., Khorshid O; National Cancer Institute, Cairo University, Cairo, Egypt., Länger F; Institute of Pathology, Hannover Medical School, Hannover, Germany., de Marinis F; Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy., Peled N; Helmesely Cancer Center, Shaare Zedek Medical Center, Jerusalem, Israel., Sheffield BS; Division of Advanced Diagnostics, William Osler Health System, Brampton, ON, Canada., Smit EF; Department of Pulmonary Diseases, Leiden University Medical Centre, Leiden, The Netherlands., Viteri S; UOMI Cancer Center, Clínica Mi Tres Torres, Barcelona, Spain., Wolf J; Lung Cancer Group Cologne, Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany., Venturini F; Merck Serono S.p.A., Rome, Italy., O'Hara RM Jr; EMD Serono, Inc., Rockland, MA, USA., Rolfo C; Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai Medical System & Icahn School of Medicine, New York, NY, USA. christian.rolfo@mssm.edu. |
المصدر: | British journal of cancer [Br J Cancer] 2024 Jul; Vol. 131 (2), pp. 212-219. Date of Electronic Publication: 2024 May 15. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK Original Publication: London, Lewis. |
مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung*/genetics , High-Throughput Nucleotide Sequencing*/methods , High-Throughput Nucleotide Sequencing*/standards , Lung Neoplasms*/genetics, Humans ; Circulating Tumor DNA/genetics ; Circulating Tumor DNA/blood |
مستخلص: | Non-small cell lung cancer is a heterogeneous disease and molecular characterisation plays an important role in its clinical management. Next-generation sequencing-based panel testing enables many molecular alterations to be interrogated simultaneously, allowing for comprehensive identification of actionable oncogenic drivers (and co-mutations) and appropriate matching of patients with targeted therapies. Despite consensus in international guidelines on the importance of broad molecular profiling, adoption of next-generation sequencing varies globally. One of the barriers to its successful implementation is a lack of accepted standards and guidelines specifically for the reporting and clinical annotation of next-generation sequencing results. Based on roundtable discussions between pathologists and oncologists, we provide best practice recommendations for the reporting of next-generation sequencing results in non-small cell lung cancer to facilitate its use and enable easy interpretation for physicians. These are intended to complement existing guidelines related to the use of next-generation sequencing (solid and liquid). Here, we discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof. The aim of these recommendations and considerations is ultimately to ensure that reports are fully interpretable, and that the most appropriate treatment options are selected based on robust molecular profiles in well-defined reports. (© 2024. The Author(s).) |
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المشرفين على المادة: | 0 (Circulating Tumor DNA) |
تواريخ الأحداث: | Date Created: 20240515 Date Completed: 20240722 Latest Revision: 20240827 |
رمز التحديث: | 20240828 |
مُعرف محوري في PubMed: | PMC11263606 |
DOI: | 10.1038/s41416-024-02709-4 |
PMID: | 38750115 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1532-1827 |
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DOI: | 10.1038/s41416-024-02709-4 |