دورية أكاديمية
أعرض في EDS

Impact of donor-specific antibody with low mean fluorescence intensity on allograft outcomes in kidney transplant.

التفاصيل البيبلوغرافية
العنوان: Impact of donor-specific antibody with low mean fluorescence intensity on allograft outcomes in kidney transplant.
المؤلفون: Kitpermkiat R; Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: Rungthiwa.kit@mahidol.ac.th., Kantachuvesiri S; Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Thotsiri S; Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Thammanichanond D; Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Histocompatibility and Immunogenetics Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Rostaing L; Nephrology, Hemodialysis, Apheresis and Transplantation, CHU Grenoble-Alps, La Tronche, France., Wiwattanathum P; Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: punlop.wiw@mahidol.ac.th.
المصدر: Transplant immunology [Transpl Immunol] 2024 Jun; Vol. 84, pp. 102054. Date of Electronic Publication: 2024 May 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Dunton Green, Sevenoaks, Kent, UK : Edward Arnold, c1993-
مواضيع طبية MeSH: Kidney Transplantation* , Graft Rejection*/immunology , Graft Rejection*/diagnosis , Isoantibodies*/blood , HLA Antigens*/immunology , Graft Survival*/immunology , Tissue Donors*, Humans ; Male ; Female ; Middle Aged ; Adult ; Allografts/immunology ; Transplantation, Homologous ; Retrospective Studies
مستخلص: Background: Immune-mediated rejection is the most common cause of allograft failure in kidney transplant (KT) patients. Exposure to alloantigen, including human leukocyte antigen (HLA), results in the production of donor-specific antibodies (DSA). There are limited data about low levels of mean fluorescence intensity (MFI) DSA, especially post-transplantation. This study evaluated allograft outcomes in KT patients with low MFI DSA.
Methods: From January 2007 to December 2021, KT patients who were tested for post-transplant DSA at Ramathibodi Hospital, Bangkok, Thailand, with the DSA MFI ≤ 1000 were evaluated. These KT patients were categorized into two groups: very low DSA (VLL; MFI = 1-500) and low DSA (LL; MFI = 501-1000). All KT patients were evaluated for the primary outcomes, such as the incidence of acute rejection, serum creatinine levels at one and five years after transplantation as well as allograft and patient survivals.
Results: Among 36 KT patients 25 were included as those with VLL and 11 as those with LL. The LL group had significantly higher T-cell mediated allograft rejection (TCMR) than the VLL group (45% vs. 12%, P = 0.04). In addition, 10 patients, 5 in the VLL group and 5 in the LL group developed antibody-mediated allograft rejection (ABMR). Both TCMR and ABMR were confirmed by biopsy results. There was a trend toward higher MFI in KT patients with ABMR than without ABMR (P = 0.22). At 5 post-transplant years, serum creatinine, allograft and patient survivals were comparable between these two groups. Furthermore, the univariate and multivariate analyzes revealed that the LL group was a high risk for rejection.
Conclusion: Low MFI DSA values after transplantation may be associated with a higher incidence of rejection, but this finding did not show differences in allograft and patient survival in this study's analysis.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Kidney transplant; Low DSA MFI; Rejection
المشرفين على المادة: 0 (Isoantibodies)
0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20240516 Date Completed: 20240530 Latest Revision: 20240530
رمز التحديث: 20240531
DOI: 10.1016/j.trim.2024.102054
PMID: 38750972
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5492
DOI:10.1016/j.trim.2024.102054