دورية أكاديمية
Metagenomic profiles of the antimicrobial resistance in traditional Chinese fermented meat products: Core resistome and co-occurrence patterns.
| العنوان: | Metagenomic profiles of the antimicrobial resistance in traditional Chinese fermented meat products: Core resistome and co-occurrence patterns. |
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| المؤلفون: | Qu T; Chinese Academy of Inspection and Quarantine, Beijing 100176, China; College of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, Jilin, China., Wang P; Chinese Academy of Inspection and Quarantine, Beijing 100176, China., Zhao X; Chinese Academy of Inspection and Quarantine, Beijing 100176, China., Liang L; Chinese Academy of Inspection and Quarantine, Beijing 100176, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Ji Q; Chinese Academy of Inspection and Quarantine, Beijing 100176, China., Ge Y; China Rural Technology Development Center, Beijing 100045, China; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China., Chen Y; Chinese Academy of Inspection and Quarantine, Beijing 100176, China. Electronic address: chenyingcaiq@163.com. |
| المصدر: | International journal of food microbiology [Int J Food Microbiol] 2024 Jun 16; Vol. 418, pp. 110740. Date of Electronic Publication: 2024 May 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8412849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3460 (Electronic) Linking ISSN: 01681605 NLM ISO Abbreviation: Int J Food Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, c1984- |
| مواضيع طبية MeSH: | Meat Products*/microbiology , Bacteria*/genetics , Bacteria*/drug effects , Bacteria*/classification , Bacteria*/isolation & purification , Drug Resistance, Bacterial*/genetics , Fermented Foods*/microbiology , Anti-Bacterial Agents*/pharmacology , Metagenomics* , Food Microbiology*, China ; Fermentation ; Metagenome ; Staphylococcus/genetics ; Staphylococcus/drug effects ; Staphylococcus/isolation & purification ; East Asian People |
| مستخلص: | Antimicrobial resistance (AMR) poses a significant challenge to global health, and the presence of antibiotic resistance genes (ARGs) in food poses a potential threat to public health. Traditional Chinese fermented meat products (FMPs) are highly favored because of their unique flavors and cultural value. However, microbial safety and the potential distribution and composition of AMR in these products remain unclear. In this study, a comprehensive analysis of bacterial composition and antibiotic-resistant populations in 216 samples of traditional fermented meat products from different regions of China was conducted using a metagenomic approach. Staphylococcus was the most abundant genus in the samples, accounting for an average abundance of 29.9 %, followed by Tetragenococcus (17.1 %), and Latilactobacillus (3.6 %). A core resistome of FMP samples was constructed for the first time using co-occurrence network analysis, which revealed the distribution and interrelationships of ARGs and bio/metal-resistant genes (BMRGs). Random forest analysis identified the lincosamide nucleotidyltransferase lnuA and the multidrug and toxic compound extrusion (MATE) transporter abeM as potential indicators for assessing the overall abundance of the core resistome. Additionally, Staphylococcus, Acinetobacter, and Pseudomonas were identified as hosts constituting the core resistome. Despite their low abundance, the latter two still serve as major reservoirs of antibiotic resistance genes. Notably, Lactococcus cremoris was identified as the key host for tetracycline resistance genes in the samples, highlighting the need for enhanced resistance monitoring in lactic acid bacteria. Based on our findings, in the microbial safety assessment of fermented meat products, beyond common foodborne pathogens, attention should be focused on detecting and controlling coagulase-negative Staphylococcus, Acinetobacter, and Pseudomonas, and addressing bacterial resistance. The quantitative detection of lnuA and abeM could provide a convenient and rapid method for assessing the overall abundance of the core resistome. Our findings have important implications for the control of bacterial resistance and prevention of pathogenic bacteria in fermented meat products. Competing Interests: Declaration of competing interest The authors declare that no competing interests exist. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antibiotic resistance gene; Bacterial hosts; Co-occurrence patterns; Core resistome; Fermented food safety; Fermented meat products |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240516 Date Completed: 20240525 Latest Revision: 20240525 |
| رمز التحديث: | 20240527 |
| DOI: | 10.1016/j.ijfoodmicro.2024.110740 |
| PMID: | 38754174 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-3460 |
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| DOI: | 10.1016/j.ijfoodmicro.2024.110740 |