دورية أكاديمية
Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis.
| العنوان: | Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis. |
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| المؤلفون: | Xu X; Department of Pediatrics, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying City, Shandong Province, China., Han W; Department of Pediatrics, Wudi People's Hospital, Binzhou City, Shandong Province, China., Han W; Department of Pediatrics, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying City, Shandong Province, China. Electronic address: hanweiping86@hotmail.com. |
| المصدر: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 May 15; Vol. 79, pp. 100384. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]- |
| مواضيع طبية MeSH: | Immunoglobulin E*/blood , Bronchiolitis*/blood , Bronchiolitis*/immunology , Nitric Oxide*/analysis , Nitric Oxide*/blood , Severity of Illness Index*, Humans ; Female ; Male ; Infant ; Case-Control Studies ; Child, Preschool ; Fractional Exhaled Nitric Oxide Testing ; Biomarkers/blood ; Biomarkers/analysis ; Reference Values ; Statistics, Nonparametric |
| مستخلص: | Objective: This article focused on the correlation between the changes of serum total Immunoglobulin E (IgE) and Fractional exhaled Nitric Oxide (FeNO) and idiosyncratic reactions in children with bronchiolitis. Methods: One hundred children with bronchiolitis and fifty healthy children were enrolled. Serum total IgE and FeNO were assessed, and the diagnostic value for bronchiolitis and the correlation with the severity of bronchiolitis were analyzed. Bronchiolitis children were divided into idiosyncratic + bronchiolitis and non-idiosyncratic + bronchiolitis groups, the relationship between serum total IgE and FeNO and idiosyncratic reaction was determined, and the diagnostic value of serum total IgE and FeNO for idiosyncratic bronchiolitis was examined. Results: FeNO in bronchiolitis children was lower than that in healthy children but there was no significant difference in serum total IgE levels between the two populations. Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children. The serum total IgE was positively correlated while FeNO was negatively correlated with the severity of bronchiolitis. Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgE and FeNO were not the risk factors for idiosyncratic bronchiolitis; Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7. Conclusion: Serum total IgE and FeNO in children with bronchiolitis are related to disease severity and idiosyncratic reaction. FeNO has a diagnostic value for bronchiolitis, but not for idiosyncratic bronchiolitis. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Bronchiolitis; Fractional exhaled nitric oxide; Idiosyncratic Reaction; Total immunoglobulin e |
| المشرفين على المادة: | 37341-29-0 (Immunoglobulin E) 31C4KY9ESH (Nitric Oxide) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240516 Date Completed: 20240524 Latest Revision: 20240527 |
| رمز التحديث: | 20240527 |
| مُعرف محوري في PubMed: | PMC11126779 |
| DOI: | 10.1016/j.clinsp.2024.100384 |
| PMID: | 38754226 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1980-5322 |
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| DOI: | 10.1016/j.clinsp.2024.100384 |