دورية أكاديمية
Thalamic contributions to the state and contents of consciousness.
| العنوان: | Thalamic contributions to the state and contents of consciousness. |
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| المؤلفون: | Whyte CJ; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia., Redinbaugh MJ; Department of Biology, Stanford University, Stanford, CA, USA. Electronic address: mredinba@stanford.edu., Shine JM; Centre for Complex Systems, The University of Sydney, Sydney, NSW, Australia; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia., Saalmann YB; Department of Psychology, University of Wisconsin - Madison, Madison, WI, USA; Wisconsin National Primate Research Center, Madison, WI, USA. |
| المصدر: | Neuron [Neuron] 2024 May 15; Vol. 112 (10), pp. 1611-1625. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Thalamus*/physiology , Consciousness*/physiology, Humans ; Animals ; Neural Pathways/physiology ; Neurons/physiology ; Cerebral Cortex/physiology ; Wakefulness/physiology |
| مستخلص: | Consciousness can be conceptualized as varying along at least two dimensions: the global state of consciousness and the content of conscious experience. Here, we highlight the cellular and systems-level contributions of the thalamus to conscious state and then argue for thalamic contributions to conscious content, including the integrated, segregated, and continuous nature of our experience. We underscore vital, yet distinct roles for core- and matrix-type thalamic neurons. Through reciprocal interactions with deep-layer cortical neurons, matrix neurons support wakefulness and determine perceptual thresholds, whereas the cortical interactions of core neurons maintain content and enable perceptual constancy. We further propose that conscious integration, segregation, and continuity depend on the convergent nature of corticothalamic projections enabling dimensionality reduction, a thalamic reticular nucleus-mediated divisive normalization-like process, and sustained coherent activity in thalamocortical loops, respectively. Overall, we conclude that the thalamus plays a central topological role in brain structures controlling conscious experience. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: conscious state; core; matrix; perception; thalamocortical |
| تواريخ الأحداث: | Date Created: 20240516 Date Completed: 20240516 Latest Revision: 20240516 |
| رمز التحديث: | 20240517 |
| DOI: | 10.1016/j.neuron.2024.04.019 |
| PMID: | 38754373 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2024.04.019 |