دورية أكاديمية
Fermented Milk Containing Lacticaseibacillus rhamnosus SNU50430 Modulates Immune Responses and Gut Microbiota in Antibiotic-Treated Mice.
| العنوان: | Fermented Milk Containing Lacticaseibacillus rhamnosus SNU50430 Modulates Immune Responses and Gut Microbiota in Antibiotic-Treated Mice. |
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| المؤلفون: | Yoon S; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea., Park S; N-Bio, Seoul National University, Seoul 08826, Republic of Korea.; KoBioLabs, Inc., Seoul 08826, Republic of Korea.; weBiom Inc., Seoul 08826, Republic of Korea., Jung SE; R&BD Center, hy Co., Ltd., Yongin 17086, Republic of Korea., Lee C; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.; Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea., Kim WK; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.; Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea., Choi ID; R&BD Center, hy Co., Ltd., Yongin 17086, Republic of Korea., Ko G; Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.; N-Bio, Seoul National University, Seoul 08826, Republic of Korea.; KoBioLabs, Inc., Seoul 08826, Republic of Korea.; Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea. |
| المصدر: | Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2024 Jun 28; Vol. 34 (6), pp. 1299-1306. Date of Electronic Publication: 2024 Apr 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society for Microbiology and Biotechnology Country of Publication: Korea (South) NLM ID: 9431852 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1738-8872 (Electronic) Linking ISSN: 10177825 NLM ISO Abbreviation: J Microbiol Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Seoul : Korean Society for Microbiology and Biotechnology Original Publication: Seoul : Korean Society for Applied Microbiology, 1991-2001. |
| مواضيع طبية MeSH: | Lacticaseibacillus rhamnosus* , Gastrointestinal Microbiome*/drug effects , Mice, Inbred BALB C* , Probiotics*/administration & dosage , Anti-Bacterial Agents*/pharmacology , Interleukin-10*/metabolism , Cultured Milk Products*/microbiology, Animals ; Female ; Mice ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/blood ; Interferon-gamma/metabolism ; Colon/microbiology ; Fermentation ; Cytokines/metabolism ; Cytokines/blood ; Feces/microbiology |
| مستخلص: | Antibiotics are used to control infectious diseases. However, adverse effects of antibiotics, such as devastation of the gut microbiota and enhancement of the inflammatory response, have been reported. Health benefits of fermented milk are established and can be enhanced by the addition of probiotic strains. In this study, we evaluated effects of fermented milk containing Lacticaseibacillus rhamnosus ( L. rhamnosus ) SNUG50430 in a mouse model with antibiotic treatment. Fermented milk containing 2 × 10 5 colony-forming units of L. rhamnosus SNUG50430 was administered to six week-old female BALB/c mice for 1 week. Interleukin (IL)-10 levels in colon samples were significantly increased ( P < 0.05) compared to water-treated mice, whereas interferon-gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were decreased, of mice treated with fermented milk containing L. rhamnosus SNUG50430-antibiotics-treated (FM+LR+Abx-treated) mice. Phylum Firmicutes composition in the gut was restored and the relative abundances of several bacteria, including the genera Coprococcus and Lactobacillus , were increased in FM+LR+Abx-treated mice compared to PBS+Abx-treated mice. Interestingly, abundances of genus Coprococcus and Lactobacillus were positively correlated with IL-5 and IL-10 levels ( P < 0.05) in colon samples and negative correlated with IFN-γ and TNF-α levels in serum samples ( P < 0.001). Acetate and butyrate were increased in mice with fermented milk and fecal microbiota of FM+LR+Abx-treated mice were highly enriched with butyrate metabolism pathway compared to water-treated mice ( P < 0.05). Thus, fermented milk containing L. rhamnosus SNUG50430 was shown to ameliorate adverse health effects caused by antibiotics through modulating immune responses and the gut microbiota. |
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| فهرسة مساهمة: | Keywords: Antibiotic; Lacticaseibacillus rhamnosus; fermented milk; gut microbiota; immunomodulation; probiotic |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 130068-27-8 (Interleukin-10) 0 (Tumor Necrosis Factor-alpha) 82115-62-6 (Interferon-gamma) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20240516 Date Completed: 20240628 Latest Revision: 20240714 |
| رمز التحديث: | 20240714 |
| مُعرف محوري في PubMed: | PMC11239404 |
| DOI: | 10.4014/jmb.2401.01012 |
| PMID: | 38755001 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1738-8872 |
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| DOI: | 10.4014/jmb.2401.01012 |