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Choriocarcinoma Syndrome: A Rare Complication's Impact on Metastatic Germ Cell Tumor Outcomes.

التفاصيل البيبلوغرافية
العنوان: Choriocarcinoma Syndrome: A Rare Complication's Impact on Metastatic Germ Cell Tumor Outcomes.
المؤلفون: Herr S; Department of Medicine, Drexel University College of Medicine, Philadelphia, USA., Garabet R; Department of Medicine, Drexel University College of Medicine, Philadelphia, USA., Tseng L; Department of Pulmonary Medicine, Kaiser Permanente Northern California, Walnut Creek, USA., Harzstark AL; Department of Urologic Oncology, Kaiser Permanente Northern California, San Francisco, USA., Russin MP; Department of Oncology, Kaiser Permanente Northern California, Walnut Creek, USA.
المصدر: Cureus [Cureus] 2024 Apr 16; Vol. 16 (4), pp. e58388. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Choriocarcinoma syndrome is a rare form of tumor lysis syndrome that predominantly occurs in patients with metastatic germ cell tumors, particularly those presenting with extensive lung metastases. We report a case of a previously healthy 37-year-old male who presented with a painless left-sided neck lump and nipples with an increased sensitivity to light touch. Workup revealed a significantly elevated beta-human chorionic gonadotropin, a testicular mass, and innumerable pulmonary metastases, suggesting metastatic non-seminomatous germ cell tumor. Following the initiation of chemotherapy with etoposide, ifosfamide, and cisplatin (VIP), the patient experienced a rapid decline in respiratory function, culminating in acute respiratory distress syndrome and subsequent death from respiratory failure six weeks after starting treatment. This case emphasizes the importance of early detection and intervention in managing non-seminomatous germ cell tumors and highlights the critical need for awareness of choriocarcinoma syndrome's risks, the challenges of treatment delays for fertility preservation, and the exploration of alternative therapeutic strategies to improve outcomes in this high-risk patient population.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Herr et al.)
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فهرسة مساهمة: Keywords: case report; choriocarcinoma; choriocarcinoma syndrome; germ cell tumor; tumor lysis syndrome
تواريخ الأحداث: Date Created: 20240517 Latest Revision: 20240518
رمز التحديث: 20240518
مُعرف محوري في PubMed: PMC11097919
DOI: 10.7759/cureus.58388
PMID: 38756265
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.58388