دورية أكاديمية
Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR).
| العنوان: | Hepatic steatosis induced by nicotine plus Coca-Cola™ is prevented by nicotinamide riboside (NR). |
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| المؤلفون: | Rivera JC; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Espinoza-Derout J; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States., Hasan KM; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States., Molina-Mancio J; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Martínez J; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Lao CJ; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Lee ML; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.; Biostatistics Department, UCLA Fielding School of Public Health, Los Angeles, CA, United States., Lee DL; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Wilson J; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States., Sinha-Hikim AP; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States., Friedman TC; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 May 02; Vol. 15, pp. 1282231. Date of Electronic Publication: 2024 May 02 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Pyridinium Compounds*/pharmacology , Mice, Inbred C57BL* , Niacinamide*/analogs & derivatives , Niacinamide*/pharmacology , Nicotine*, Animals ; Mice ; Male ; Non-alcoholic Fatty Liver Disease/prevention & control ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/etiology ; Fatty Liver/prevention & control ; Fatty Liver/metabolism ; Fatty Liver/chemically induced ; High Fructose Corn Syrup/adverse effects ; Liver/metabolism ; Liver/drug effects ; Liver/pathology ; Oxidative Stress/drug effects |
| مستخلص: | Introduction: Cigarettes containing nicotine (Nic) are a risk factor for the development of cardiovascular and metabolic diseases. We reported that Nic delivered via injections or e-cigarette vapor led to hepatic steatosis in mice fed with a high-fat diet. High-fructose corn syrup (HFCS) is the main sweetener in sugar-sweetened beverages (SSBs) in the US. Increased consumption of SSBs with HFCS is associated with increased risks of non-alcoholic fatty liver disease (NAFLD). Nicotinamide riboside (NR) increases mitochondrial nicotinamide adenine dinucleotide (NAD + ) and protects mice against hepatic steatosis. This study evaluated if Nic plus Coca-Cola ™ (Coke) with HFCS can cause hepatic steatosis and that can be protected by NR. Methods: C57BL/6J mice received twice daily intraperitoneal (IP) injections of Nic or saline and were given Coke (HFCS), or Coke with sugar, and NR supplementation for 10 weeks. Results: Our results show that Nic+Coke caused increased caloric intake and induced hepatic steatosis, and the addition of NR prevented these changes. Western blot analysis showed lipogenesis markers were activated (increased cleavage of the sterol regulatory element-binding protein 1 [SREBP1c] and reduction of phospho-Acetyl-CoA Carboxylase [p-ACC]) in the Nic+Coke compared to the Sal+Water group. The hepatic detrimental effects of Nic+Coke were mediated by decreased NAD + signaling, increased oxidative stress, and mitochondrial damage. NR reduced oxidative stress and prevented mitochondrial damage by restoring protein levels of Sirtuin1 (Sirt1) and peroxisome proliferator-activated receptor coactivator 1-alpha (PGC1) signaling. Conclusion: We conclude that Nic+Coke has an additive effect on producing hepatic steatosis, and NR is protective. This study suggests concern for the development of NAFLD in subjects who consume nicotine and drink SSBs with HFCS. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Rivera, Espinoza-Derout, Hasan, Molina-Mancio, Martínez, Lao, Lee, Lee, Wilson, Sinha-Hikim and Friedman.) |
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| معلومات مُعتمدة: | R16 GM153622 United States GM NIGMS NIH HHS; SC2 GM135127 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: NAD+; hepatic steatosis; high-fructose corn syrup; nicotinamide riboside; nicotine |
| المشرفين على المادة: | 0 (nicotinamide-beta-riboside) |
| تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240517 Latest Revision: 20240827 |
| رمز التحديث: | 20240827 |
| مُعرف محوري في PubMed: | PMC11097688 |
| DOI: | 10.3389/fendo.2024.1282231 |
| PMID: | 38756999 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2024.1282231 |