دورية أكاديمية
Prevalence of Thyroid Nodules in Residents of Ukraine Exposed as Children or Adolescents to Iodine-131 from the Chornobyl Accident.
| العنوان: | Prevalence of Thyroid Nodules in Residents of Ukraine Exposed as Children or Adolescents to Iodine-131 from the Chornobyl Accident. |
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| المؤلفون: | Cahoon EK; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Grimm E; University of Colorado School of Medicine, Aurora, CO, USA., Mabuchi K; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Mai JZ; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Zhang R; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Drozdovitch V; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Hatch M; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Little MP; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Peters KO; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Bogdanova TI; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Shelkovoy E; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Shpak VM; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Terekhova G; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Zamotayeva G; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Pasteur IP; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Masiuk SV; State Institution 'National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine', Kyiv, Ukraine., Chepurny M; State Institution 'National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine', Kyiv, Ukraine., Zablotska LB; Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA, USA., McConnell R; The New York Thyroid Center, Columbia University, New York, NY, USA., O'Kane P; Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA., Tronko MD; V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine., Brenner AV; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.; Radiation Effects Research Foundation, Epidemiology, Hiroshima, Japan. |
| المصدر: | Thyroid : official journal of the American Thyroid Association [Thyroid] 2024 Jul; Vol. 34 (7), pp. 890-898. Date of Electronic Publication: 2024 Jun 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Publishers Country of Publication: United States NLM ID: 9104317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9077 (Electronic) Linking ISSN: 10507256 NLM ISO Abbreviation: Thyroid Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Mary Ann Liebert Publishers, |
| مواضيع طبية MeSH: | Thyroid Nodule*/epidemiology , Thyroid Nodule*/diagnostic imaging , Chernobyl Nuclear Accident* , Iodine Radioisotopes*/adverse effects, Humans ; Ukraine/epidemiology ; Adolescent ; Child ; Male ; Prevalence ; Female ; Cross-Sectional Studies ; Young Adult ; Radiation Exposure/adverse effects ; Child, Preschool ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/etiology ; Thyroid Neoplasms/diagnostic imaging ; Ultrasonography ; Radiation Dosage ; Neoplasms, Radiation-Induced/epidemiology ; Risk Factors |
| مستخلص: | Background: Although childhood exposure to radioactive iodine-131 (I-131) is an established risk factor for thyroid cancer, evidence for an association with thyroid nodules is less clear. The objective of this study is to evaluate the association between childhood I-131 exposure and prevalence of ultrasound-detected thyroid nodules overall and by nodule histology/cytology (neoplastic/suspicious/non-neoplastic), size (<10 mm/≥10 mm), and number (single/multiple). Methods: This is a cross-sectional study of radiation dose (mean = 0.53 gray, range: 0.0003-31 gray) and screen-detected thyroid nodules conducted in 1998-2000 (median population age 21.5 years) in a cohort of 13,243 residents of Ukraine who were under 18 years at the time of the Chornobyl accident on April 26, 1986. Excess odds ratios per gray (excess odds ratio [EOR]/Gy) and confidence intervals (CIs) were estimated using logistic regression. Results: Among 13,078 eligible individuals, we identified 358 (2.7%) with at least one thyroid nodule. Significantly increased dose-response associations were found for all nodules and nodule groups with doses <5 Gy except individuals with non-neoplastic nodules. Among individuals with doses <5 Gy, the EOR/Gy for neoplastic nodules (5.35; CI: 2.19-15.5) was significantly higher than for non-neoplastic nodules (0.24; CI: 0.07-0.74), but the EOR/Gy did not vary by nodule size or number. Conclusions: Childhood exposure to I-131 is associated with an increased risk of thyroid nodules detected 12-14 years following exposure, and the risk for neoplastic nodules is higher than for non-neoplastic nodules. Analyses of incident thyroid nodules may help clarify dose-response patterns by nodule characteristics and provide insights into thyroid nodule etiology. |
| فهرسة مساهمة: | Keywords: Chernobyl; Chornobyl; Ukraine; radiation |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Iodine-131) |
| تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240716 Latest Revision: 20240716 |
| رمز التحديث: | 20240717 |
| DOI: | 10.1089/thy.2023.0654 |
| PMID: | 38757581 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-9077 |
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| DOI: | 10.1089/thy.2023.0654 |