دورية أكاديمية
1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts.
العنوان: | 1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts. |
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المؤلفون: | Yang H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Jing M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Tian C; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Li B; Department of Cardiology, Peking University First Hospital, Beijing 100034, China., Liao W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Wang W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Li Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Wang X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Duan G; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Sun Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Huang Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Wu L; Department of Cardiology, Peking University First Hospital, Beijing 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China. |
المصدر: | Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12676-12694. Date of Electronic Publication: 2024 May 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
مواضيع طبية MeSH: | Piperazines*/pharmacology , Piperazines*/chemistry , Piperazines*/chemical synthesis , Piperazines*/pharmacokinetics, Animals ; Rabbits ; HEK293 Cells ; Humans ; Anti-Arrhythmia Agents/pharmacology ; Anti-Arrhythmia Agents/chemistry ; Anti-Arrhythmia Agents/pharmacokinetics ; Anti-Arrhythmia Agents/chemical synthesis ; Sodium Channel Blockers/pharmacology ; Sodium Channel Blockers/chemistry ; Sodium Channel Blockers/chemical synthesis ; Sodium Channel Blockers/pharmacokinetics ; Mice ; Long QT Syndrome/chemically induced ; Structure-Activity Relationship ; Male ; NAV1.5 Voltage-Gated Sodium Channel/metabolism ; Heart/drug effects ; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors ; Ether-A-Go-Go Potassium Channels/metabolism ; ERG1 Potassium Channel/antagonists & inhibitors ; ERG1 Potassium Channel/metabolism ; Cardiac Conduction System Disease |
مستخلص: | Late sodium current ( I |
المشرفين على المادة: | 0 (Piperazines) 0 (Anti-Arrhythmia Agents) 0 (Sodium Channel Blockers) 0 (NAV1.5 Voltage-Gated Sodium Channel) 0 (Ether-A-Go-Go Potassium Channels) 0 (ERG1 Potassium Channel) |
SCR Disease Name: | Long QT syndrome type 3 |
تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240808 Latest Revision: 20240812 |
رمز التحديث: | 20240813 |
DOI: | 10.1021/acs.jmedchem.4c00677 |
PMID: | 38757601 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-4804 |
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DOI: | 10.1021/acs.jmedchem.4c00677 |