دورية أكاديمية
FMRP regulates postnatal neuronal migration via MAP1B.
| العنوان: | FMRP regulates postnatal neuronal migration via MAP1B. |
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| المؤلفون: | Messaoudi S; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Allam A; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Stoufflet J; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France.; Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, University of Liège, CHU Sart Tilman, Liège, Belgium., Paillard T; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Le Ven A; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France.; Institut Curie, Paris, France., Fouquet C; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Doulazmi M; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Trembleau A; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France., Caille I; Sorbonne Université, CNRS UMR8246, Inserm U1130, Institut de Biologie Paris Seine (IBPS), Neuroscience Paris Seine (NPS), Paris, France.; Université de Paris, Paris, France. |
| المصدر: | ELife [Elife] 2024 May 17; Vol. 12. Date of Electronic Publication: 2024 May 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
| مواضيع طبية MeSH: | Cell Movement* , Fragile X Mental Retardation Protein*/metabolism , Fragile X Mental Retardation Protein*/genetics , Microtubule-Associated Proteins*/metabolism , Microtubule-Associated Proteins*/genetics , Neurons*/metabolism, Animals ; Mice ; Fragile X Syndrome/metabolism ; Fragile X Syndrome/genetics ; Gene Knockdown Techniques ; Mice, Knockout |
| مستخلص: | The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein). Neuronal migration is an essential step of brain development allowing displacement of neurons from their germinal niches to their final integration site. The precise role of FMRP in neuronal migration remains largely unexplored. Using live imaging of postnatal rostral migratory stream (RMS) neurons in Fmr1 -null mice, we observed that the absence of FMRP leads to delayed neuronal migration and altered trajectory, associated with defects of centrosomal movement. RNA-interference-induced knockdown of Fmr1 shows that these migratory defects are cell-autonomous. Notably, the primary Fmrp mRNA target implicated in these migratory defects is microtubule-associated protein 1B (MAP1B). Knocking down MAP1B expression effectively rescued most of the observed migratory defects. Finally, we elucidate the molecular mechanisms at play by demonstrating that the absence of FMRP induces defects in the cage of microtubules surrounding the nucleus of migrating neurons, which is rescued by MAP1B knockdown. Our findings reveal a novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton. Competing Interests: SM, AA, JS, TP, AL, CF, MD, AT, IC No competing interests declared (© 2023, Messaoudi et al.) |
| التعليقات: | Update of: bioRxiv. 2023 Dec 28:2023.03.06.530447. doi: 10.1101/2023.03.06.530447. (PMID: 36945472) |
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| معلومات مُعتمدة: | R01 DC017989 United States DC NIDCD NIH HHS; ANR-20-CE16-0016 Agence Nationale de la Recherche; R01-DC-017989 United States DC NIDCD NIH HHS; GRT-2017A/1659 Fondation Jérôme Lejeune |
| فهرسة مساهمة: | Keywords: FMRP; MAP1B; cytoskeleton; fragile X messenger ribonucleoprotein; fragile X syndrome; microtubule-associated protein 1B; mouse; neuronal migration; neuroscience |
| المشرفين على المادة: | 0 (Fmr1 protein, mouse) 139135-51-6 (Fragile X Mental Retardation Protein) 0 (microtubule-associated protein 1B) 0 (Microtubule-Associated Proteins) |
| تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240517 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11101172 |
| DOI: | 10.7554/eLife.88782 |
| PMID: | 38757694 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2050-084X |
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| DOI: | 10.7554/eLife.88782 |