دورية أكاديمية
أعرض في EDS

Characterization of clinical serum cardiac biomarker levels in individuals with Friedreich ataxia.

التفاصيل البيبلوغرافية
العنوان: Characterization of clinical serum cardiac biomarker levels in individuals with Friedreich ataxia.
المؤلفون: Lynch DR; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States of America. Electronic address: lynchd@pennmedicine.upenn.edu., Sharma S; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Hearle P; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Greeley N; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Gunther K; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Keita M; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Strawser C; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Hauser L; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Park C; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Schadt K; Divisions of Neurology Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America., Lin KY; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States of America; Divisions of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America.
المصدر: Journal of the neurological sciences [J Neurol Sci] 2024 Jun 15; Vol. 461, pp. 123053. Date of Electronic Publication: 2024 May 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, <19 ->
مواضيع طبية MeSH: Friedreich Ataxia*/blood , Friedreich Ataxia*/diagnosis , Biomarkers*/blood , Troponin I*/blood , Natriuretic Peptide, Brain*/blood, Humans ; Female ; Male ; Adult ; Middle Aged ; Young Adult ; Troponin T/blood ; Adolescent ; Cardiomyopathies/blood ; Cardiomyopathies/diagnosis ; Cohort Studies
مستخلص: Friedreich ataxia is a progressive autosomal recessive neurodegenerative disorder characterized by ataxia, dyscoordination, and cardiomyopathy. A subset of patients with Friedreich ataxia have elevated levels of serum cardiac troponin I, but associations with disease outcomes and features of cardiomyopathy remain unclear. In this study, we characterized clinically obtained serum cardiac biomarker levels including troponin I, troponin T, and B-type natriuretic peptide in subjects with Friedreich ataxia and evaluated their association with markers of disease. While unprovoked troponin I levels were elevated in 36% of the cohort, cTnI levels associated with a cardiac event (provoked) were higher than unprovoked levels. In multivariate linear regression models, younger age predicted increased troponin I values, and in logistic regression models younger age, female sex, and marginally longer GAA repeat length predicted abnormal troponin I levels. In subjects with multiple assessments, mean unprovoked troponin I levels decreased slightly over time. The presence of abnormal troponin I values and their levels were predicted by echocardiographic measures of hypertrophy. In addition, troponin I levels predicted long-term markers of clinical cardiac dysfunction over time to a modest degree. Consequently, troponin I values provide a marker of hypertrophy but only a minimally predictive biomarker for later cardiac manifestations of disease such as systolic dysfunction or arrhythmia.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Cardiomyopathy; Hypertrophy; Mitochondria
المشرفين على المادة: 0 (Biomarkers)
0 (Troponin I)
114471-18-0 (Natriuretic Peptide, Brain)
0 (Troponin T)
تواريخ الأحداث: Date Created: 20240517 Date Completed: 20240611 Latest Revision: 20240611
رمز التحديث: 20240612
DOI: 10.1016/j.jns.2024.123053
PMID: 38759249
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5883
DOI:10.1016/j.jns.2024.123053