دورية أكاديمية
أعرض في EDS

Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation.

التفاصيل البيبلوغرافية
العنوان: Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation.
المؤلفون: Ortiz HR; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA., Cruz Flores P; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA., Podgorski J; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA., Ramonett A; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA., Ahmed T; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA., Hempel N; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Charest PG; Department of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85724, USA., Ellis NA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA., Langlais PR; Department of Medicine, University of Arizona, Tucson, AZ 85724, USA., Montfort WR; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA., Mythreye K; Department of Pathology, University of Alabama at Birmingham, AL 35294, USA., Kumar S; Division of Biology, Indian Institute of Science Education & Research Tirupati, Mangalam Tirupati 517507, India. Electronic address: sanjay@iisertirupati.ac.in., Lee NY; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA; Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85724, USA; Comprehensive Cancer Center, University of Arizona, Tucson, AZ 85724, USA. Electronic address: namlee@email.arizona.edu.
المصدر: Neoplasia (New York, N.Y.) [Neoplasia] 2024 Jul; Vol. 53, pp. 101003. Date of Electronic Publication: 2024 May 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : [Amsterdam] : Elsevier
Original Publication: New York, NY : Stockton Press, c1999-
مواضيع طبية MeSH: Microtubules*/metabolism , Endoplasmic Reticulum*/metabolism , MAP Kinase Kinase Kinases*/metabolism , MAP Kinase Kinase Kinases*/genetics , Signal Transduction*, Humans ; Acetylation ; Animals ; Microtubule-Associated Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Acetyltransferases/metabolism ; Acetyltransferases/genetics ; Endoplasmic Reticulum Stress ; Mice ; Microtubule Proteins
مستخلص: Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled by extracellular signals remains unknown. Here we report that TAK1, a kinase responsive to various growth factors and cytokines including TGF-β and TNF-α, triggers ER tubulation by activating αTAT1, an MT-acetylating enzyme that enhances ER-sliding. We show that this TAK1/αTAT1-dependent ER remodeling promotes cell survival by actively downregulating BOK, an ER membrane-associated proapoptotic effector. While BOK is normally protected from degradation when complexed with IP3R, it is rapidly degraded upon their dissociation during the ER sheets-to-tubules conversion. These findings demonstrate a distinct mechanism of ligand-induced ER remodeling and suggest that the TAK1/αTAT1 pathway may be a key target in ER stress and dysfunction.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024. Published by Elsevier Inc.)
References: Trends Cell Biol. 2016 Dec;26(12):934-943. (PMID: 27339937)
Nature. 2014 Jan 16;505(7483):335-43. (PMID: 24429632)
Front Cell Dev Biol. 2020 Sep 15;8:574338. (PMID: 33043006)
Curr Biol. 2020 Mar 23;30(6):972-987.e12. (PMID: 32032506)
Biochem Biophys Res Commun. 2017 Jan 1;482(1):8-14. (PMID: 27836544)
Cell Mol Life Sci. 2015 Nov;72(22):4237-55. (PMID: 26227334)
Cancer Res. 2015 Jan 1;75(1):203-15. (PMID: 25503560)
Curr Biol. 2011 Nov 22;21(22):R922-4. (PMID: 22115460)
Oncogene. 2022 Feb;41(9):1376-1382. (PMID: 35091677)
Digestion. 2020;101(6):794-806. (PMID: 31563901)
Elife. 2016 Dec 13;5:. (PMID: 27976998)
J Biol Chem. 2016 May 27;291(22):11820-8. (PMID: 27053113)
Cell. 2009 Aug 7;138(3):549-61. (PMID: 19665976)
Cell Death Dis. 2018 Jan 26;9(2):125. (PMID: 29374142)
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21517-22. (PMID: 21068373)
Cell Death Differ. 2018 Mar;25(4):708-720. (PMID: 29229991)
Nat Rev Mol Cell Biol. 2012 Oct;13(10):607-25. (PMID: 22992592)
Nat Commun. 2018 Apr 27;9(1):1696. (PMID: 29703898)
Sci Adv. 2020 Dec 16;6(51):. (PMID: 33328230)
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2104309119. (PMID: 35377783)
Lab Invest. 2022 Jan;102(1):80-89. (PMID: 34508164)
Nat Commun. 2021 Jan 25;12(1):568. (PMID: 33495454)
Nature. 2022 Jan;601(7891):132-138. (PMID: 34912111)
Nature. 2009 Aug 20;460(7258):978-83. (PMID: 19633650)
Annu Rev Biochem. 2015;84:791-811. (PMID: 25580528)
Nat Cell Biol. 2017 Apr;19(4):391-398. (PMID: 28250419)
J Biol Chem. 2013 Aug 30;288(35):25340-25349. (PMID: 23884412)
J Cell Biol. 2010 Aug 9;190(3):363-75. (PMID: 20696706)
Cell. 2010 Nov 24;143(5):774-88. (PMID: 21111237)
Cell. 2016 Apr 7;165(2):421-33. (PMID: 26949185)
J Cell Biol. 2007 Dec 3;179(5):895-909. (PMID: 18056408)
Nature. 2013 Oct 24;502(7472):567-70. (PMID: 24097348)
Science. 2017 Apr 21;356(6335):328-332. (PMID: 28428427)
Nat Commun. 2013;4:1962. (PMID: 23748901)
Mol Biol Cell. 2014 Jun 15;25(12):1854-66. (PMID: 24743598)
J Cell Sci. 2016 Jun 1;129(11):2213-23. (PMID: 27076518)
J Biol Chem. 2013 Jul 12;288(28):20334-50. (PMID: 23720746)
Crit Rev Biochem Mol Biol. 2019 Apr;54(2):103-118. (PMID: 31023093)
Science. 2011 Oct 21;334(6054):358-62. (PMID: 21885730)
J Cell Biol. 2020 Aug 3;219(8):. (PMID: 32556066)
Mol Cell Biol. 2013 Mar;33(6):1114-23. (PMID: 23275437)
Eur J Cell Biol. 2012 Nov-Dec;91(11-12):950-60. (PMID: 22902175)
Cell Mol Life Sci. 2016 Jan;73(1):79-94. (PMID: 26433683)
J Cell Biol. 2011 Apr 18;193(2):333-46. (PMID: 21502358)
J Cell Sci. 2010 Oct 15;123(Pt 20):3447-55. (PMID: 20930140)
معلومات مُعتمدة: R01 CA275036 United States CA NCI NIH HHS; R35 GM148171 United States GM NIGMS NIH HHS; P30 CA023074 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Alpha TAT1; BOK; Endoplasmic reticulum; Microtubules; TAK1; TGF-beta
المشرفين على المادة: EC 2.7.11.25 (MAP Kinase Kinase Kinases)
EC 2.7.11.25 (MAP kinase kinase kinase 7)
EC 2.3.1.108 (ATAT1 protein, human)
0 (Microtubule-Associated Proteins)
EC 2.3.1.- (Acetyltransferases)
0 (Microtubule Proteins)
تواريخ الأحداث: Date Created: 20240517 Date Completed: 20240525 Latest Revision: 20240606
رمز التحديث: 20240606
مُعرف محوري في PubMed: PMC11127537
DOI: 10.1016/j.neo.2024.101003
PMID: 38759377
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5586
DOI:10.1016/j.neo.2024.101003