دورية أكاديمية
Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken.
| العنوان: | Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken. |
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| المؤلفون: | Wu X; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Zhang Z; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Li Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Zhao Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Ren Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Tian Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China., Hou M; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Guo Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China., Li Q; Henan zhumadian agricultural school, zhumadian, 463000, China., Tian W; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Jiang R; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Zhang Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Gong Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Li H; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Li G; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Liu X; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Kang X; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Li D; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China., Tian Y; College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China. Electronic address: tianyadong@henau.edu.cn. |
| المصدر: | Poultry science [Poult Sci] 2024 Jul; Vol. 103 (7), pp. 103820. Date of Electronic Publication: 2024 May 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Cambridge, UK] : Elsevier Original Publication: Champaign Il : Poultry Science Association |
| مواضيع طبية MeSH: | Chickens*/genetics , Chickens*/metabolism , Gonadotropin-Releasing Hormone*/metabolism , Gonadotropin-Releasing Hormone*/genetics , Tachykinins*/genetics , Tachykinins*/metabolism , Protein Precursors*/genetics , Protein Precursors*/metabolism , Avian Proteins*/genetics , Avian Proteins*/metabolism, Animals ; Estrogens/metabolism ; Enkephalins/genetics ; Enkephalins/metabolism ; Gene Expression Regulation/drug effects ; Female ; Male |
| مستخلص: | The "KNDy neurons" located in the hypothalamic arcuate nucleus (ARC) of mammals are known to co-express kisspeptin, neurokinin B (NKB), and dynorphin (DYN), and have been identified as key mediators of the feedback regulation of steroid hormones on gonadotropin-releasing hormone (GnRH). However, in birds, the genes encoding kisspeptin and its receptor GPR54 are genomic lost, leaving unclear mechanisms for feedback regulation of GnRH by steroid hormones. Here, the genes tachykinin 3 (TAC3) and prodynorphin (PDYN) encoding chicken NKB and DYN neuropeptides were successfully cloned. Temporal expression profiling indicated that TAC3, PDYN and their receptor genes (TACR3, OPRK1) were mainly expressed in the hypothalamus, with significantly higher expression at 30W than at 15W. Furthermore, overexpression or interference of TAC3 and PDYN can regulate the GnRH mRNA expression. In addition, in vivo and in vitro assays showed that estrogen (E2) could promote the mRNA expression of TAC3, PDYN, and GnRH, as well as the secretion of GnRH/LH. Mechanistically, E2 could dimerize the nuclear estrogen receptor 1 (ESR1) to regulate the expression of TAC3 and PDYN, which promoted the mRNA and protein expression of GnRH gene as well as the secretion of GnRH. In conclusion, these results revealed that E2 could regulate the GnRH expression through TAC3 and PDYN systems, providing novel insights for reproductive regulation in chickens. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: GnRH; chicken; estrogen; prodynorphin; tachykinin 3 |
| المشرفين على المادة: | 33515-09-2 (Gonadotropin-Releasing Hormone) 0 (Tachykinins) 0 (Protein Precursors) 0 (Avian Proteins) 93443-35-7 (preproenkephalin) 0 (Estrogens) 0 (Enkephalins) |
| تواريخ الأحداث: | Date Created: 20240517 Date Completed: 20240622 Latest Revision: 20240622 |
| رمز التحديث: | 20240623 |
| مُعرف محوري في PubMed: | PMC11127269 |
| DOI: | 10.1016/j.psj.2024.103820 |
| PMID: | 38759565 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-3171 |
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| DOI: | 10.1016/j.psj.2024.103820 |