دورية أكاديمية
أعرض في EDS

Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications.

التفاصيل البيبلوغرافية
العنوان: Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications.
المؤلفون: Medappa M; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Pospíšilová P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., John LN; Faculty of Medicine, University of Barcelona, Barcelona, Spain; National Department of Health, Aopi Centre, Port Moresby, Papua New Guinea., González-Beiras C; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Fight Infectious Diseases Foundation, Hospital Universitari Germans Traís i Pujol, Badalona, Spain; Universitat Autónoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallés), Spain., Mitjà O; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Fight Infectious Diseases Foundation, Hospital Universitari Germans Traís i Pujol, Badalona, Spain; Universitat Autónoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallés), Spain., Šmajs D; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: dsmajs@med.muni.cz.
المصدر: Acta tropica [Acta Trop] 2024 Aug; Vol. 256, pp. 107254. Date of Electronic Publication: 2024 May 16.
نوع المنشور: Journal Article; Case Reports
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Basel.
مواضيع طبية MeSH: Yaws*/microbiology , Coinfection*/microbiology , Treponema pallidum*/genetics , Treponema pallidum*/isolation & purification , Treponema pallidum*/classification , Genotype*, Humans ; Papua New Guinea ; Child, Preschool ; Phylogeny ; Male ; DNA, Bacterial/genetics ; Sequence Analysis, DNA ; Treponema
مستخلص: The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, J E 11, and T E 13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely T E 13 and J E 11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or inter-subspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Coinfection; Inter-strain recombination; PCR chimeric clones; TPE allelic profiles; Treponema pallidum subsp. pertenue (TPE); Yaws
المشرفين على المادة: 0 (DNA, Bacterial)
SCR Organism: Treponema pallidum subsp. pertenue
تواريخ الأحداث: Date Created: 20240517 Date Completed: 20240617 Latest Revision: 20240617
رمز التحديث: 20240618
DOI: 10.1016/j.actatropica.2024.107254
PMID: 38759832
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6254
DOI:10.1016/j.actatropica.2024.107254