دورية أكاديمية
Enhancement of mineral density and mechanical properties in root caries treated with silver diammine fluoride and glass ionomer cement, with emphasis on silver ion distribution.
| العنوان: | Enhancement of mineral density and mechanical properties in root caries treated with silver diammine fluoride and glass ionomer cement, with emphasis on silver ion distribution. |
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| المؤلفون: | Chen X; Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-8549, Japan., Inoue G; Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-8549, Japan. Electronic address: inoue.ope@tmd.ac.jp., Fan L; Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-8549, Japan., Sekizawa O; Research & Utilization Division, Japan Synchrotron Radiation Research Institute (JASRI), SPring-8, 1-1-1 Kouto, Sayo-cho, Hyogo 679-5198, Japan., Nitta K; Research & Utilization Division, Japan Synchrotron Radiation Research Institute (JASRI), SPring-8, 1-1-1 Kouto, Sayo-cho, Hyogo 679-5198, Japan., Ikeda M; Department of Oral Biomedical Engineering, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8549, Japan., Shimada Y; Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-8549, Japan. |
| المصدر: | Journal of dentistry [J Dent] 2024 Jul; Vol. 146, pp. 105041. Date of Electronic Publication: 2024 May 16. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kidlington : Elsevier Original Publication: Bristol, Eng., Wright. |
| مواضيع طبية MeSH: | Root Caries*/drug therapy , Glass Ionomer Cements*/chemistry , Glass Ionomer Cements*/therapeutic use , Silver Compounds*/therapeutic use , X-Ray Microtomography*/methods , Dentin*/drug effects , Dentin*/diagnostic imaging , Silver*/therapeutic use , Silver*/chemistry , Hardness* , Quaternary Ammonium Compounds*/therapeutic use , Cariostatic Agents*/therapeutic use, Humans ; Fluorides, Topical/therapeutic use ; Tooth Remineralization/methods ; Dental Restoration, Permanent/methods ; Spectrometry, X-Ray Emission |
| مستخلص: | Objectives: This study aimed to measure the distribution of silver ion (Ag + ), mineral recovery, and nanohardness in carious lesions and comprehensively evaluate the degree of dentin restoration. Methods: Sixty human teeth with root caries were randomly assigned to the control, silver diammine fluoride (SDF) [Safo], and SDF+Glass ionomer cement (GIC) treatment [Safo+Fuji] groups. Micro-computed tomography (micro-CT) was performed at five time points for each sample before/after treatment to evaluate mineral density within and around carious lesions. Three months following treatment, 12 samples were selected for synchrotron radiation X-ray fluorescence analysis to evaluate Ag + distribution, while 15 samples were selected for nanoindentation. Data were analyzed using Dunnett's T3 test for micro-CT and Wilcoxon rank sum test with Bonferroni correction (p = 0.017) for nanoindentation. The correlation between hardness and mineral change was analyzed using the Spearman rank correlation coefficient. Results: The Safo and Safo+Fuji groups showed significantly higher mineral recovery rates than did the control group (p < 0.001). In the Safo group, Ag + accumulated in the deeper layers rather than the superficial layer of caries. In the Safo+Fuji group, Ag + was found evenly distributed throughout caries, with only a few Ag + detected in the GIC layer. Hardness in the Safo+Fuji group was significantly higher compared with the Safo group at depths in the range of 10-50 µm. Conclusion: In the presence of GICs, SDF exhibited high remineralization capacity when diffusing throughout carious lesions over time. Combined treatment with SDF and GIC could strengthen root dentin even in the presence of caries. Clinical Significance: We found that combination treatment with SDF and GIC could increase mineral density in caries and improve the hardness of the tooth structure compared with fluoride-based agents alone. These findings might pave the way for future clinical trials to determine the therapeutic potential of nanotechnology-based restorative materials. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dental caries; Dentin restoration; Glass ionomer cement; Micro-computed tomography; Silver diammine fluoride; Synchrotron radiation X-ray fluorescence analysis |
| المشرفين على المادة: | 0 (Glass Ionomer Cements) 0 (Silver Compounds) DDU19UEV1Y (silver diamine fluoride) 3M4G523W1G (Silver) 0 (Quaternary Ammonium Compounds) 0 (Cariostatic Agents) 0 (Fluorides, Topical) |
| تواريخ الأحداث: | Date Created: 20240518 Date Completed: 20240615 Latest Revision: 20240617 |
| رمز التحديث: | 20240618 |
| DOI: | 10.1016/j.jdent.2024.105041 |
| PMID: | 38762076 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-176X |
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| DOI: | 10.1016/j.jdent.2024.105041 |