دورية أكاديمية
Sex differences in transcatheter aortic valve replacement outcomes among patients with bicuspid aortic stenosis.
| العنوان: | Sex differences in transcatheter aortic valve replacement outcomes among patients with bicuspid aortic stenosis. |
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| المؤلفون: | Rivera FB; Department of Medicine, Lincoln Medical Center, New York, NY, USA. Electronic address: frederick.berro.rivera@gmail.com., Cha SW; Cebu Institute of Medicine, Cebu City, Philippines., Redula SC; Cebu Institute of Medicine, Cebu City, Philippines., Liston MBO; Cebu Institute of Medicine, Cebu City, Philippines., Ong EP; University of the Philippines Manila, Manila City, Philippines., Bantayan NRB; University of the Philippines Manila, Manila City, Philippines., Kaur G; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Volgman AS; Department of Cardiology, Rush University Medical Center, Chicago, IL, USA., Mamas MA; Keele Cardiovascular Research Group, Center for Prognosis Research, Keele University, Stoke-on-Trent, UK. |
| المصدر: | Heart & lung : the journal of critical care [Heart Lung] 2024 Sep-Oct; Vol. 67, pp. 144-151. Date of Electronic Publication: 2024 May 18. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0330057 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3288 (Electronic) Linking ISSN: 01479563 NLM ISO Abbreviation: Heart Lung Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: St. Louis, Mosby. |
| مواضيع طبية MeSH: | Transcatheter Aortic Valve Replacement*/methods , Transcatheter Aortic Valve Replacement*/statistics & numerical data , Transcatheter Aortic Valve Replacement*/adverse effects , Aortic Valve Stenosis*/surgery , Aortic Valve Stenosis*/epidemiology , Aortic Valve Stenosis*/complications , Bicuspid Aortic Valve Disease*/surgery , Bicuspid Aortic Valve Disease*/complications , Hospital Mortality*/trends, Humans ; Male ; Female ; Aged ; Sex Factors ; United States/epidemiology ; Aged, 80 and over ; Retrospective Studies ; Postoperative Complications/epidemiology ; Treatment Outcome ; Aortic Valve/surgery ; Aortic Valve/abnormalities ; Risk Factors ; Heart Valve Diseases/surgery ; Heart Valve Diseases/complications |
| مستخلص: | Background: Despite comprising almost half of all patients undergoing valvular repair, data on transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis (BAS) are limited. Objective: We aimed to evaluate whether there are any sex differences in trends and outcomes of TAVR in this population. Methods: We utilized the National Inpatient Sample from 2012 to 2020 to identify admissions with BAS who underwent TAVR and analyzed trends and outcomes. Our primary outcome was in-hospital mortality and secondary outcomes were in-hospital complications. We used two models to adjust for demographics (A) and interventions (B). Results: Between 2012 to 2020, there were 76,540 hospitalizations for BAS patients who underwent AVR, among which 6,010 (7.9 %) underwent TAVR. There was an overall increasing trend in number of TAVR cases with a decreasing trend in mortality (2013: 8.7 %, 2020: 1.3 %). TAVR was performed more in males (61.1% vs 38.9 %). Despite the worse baseline characteristics in males, in-hospital mortality (2.4% vs. 1.5 %; OR: 1.584; 95 % CI: 0.621-4.038; p = 0.335) and secondary outcomes were similar across both sexes, even after adjusting for demographics and interventions. Conclusion: TAVR in BAS has grown rapidly in the last decade. Males comprised the majority and had more comorbidities, but mortality and complications were similar in both sexes. Despite the increasing number of cases, a decreasing trend in mortality was observed for both sexes ultimately approaching that of SAVR, suggesting that TAVR may be a safe alternative among eligible males and females with bicuspid AS. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bicuspid aortic valve; Outcomes; TAVR; Trends |
| تواريخ الأحداث: | Date Created: 20240519 Date Completed: 20240630 Latest Revision: 20240630 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1016/j.hrtlng.2024.05.003 |
| PMID: | 38762962 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1527-3288 |
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| DOI: | 10.1016/j.hrtlng.2024.05.003 |