التفاصيل البيبلوغرافية
| العنوان: |
Characterization of Bisphosphonate Hydrate Crystals by Phosphorus K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy. |
| المؤلفون: |
Ito N; Analytical Research & Development Laboratories, Sumitomo Pharma Co., Ltd., Ito M; Faculty of Pharmaceutical Sciences, Toho University., Suzuki H; Faculty of Pharmaceutical Sciences, Toho University., Noguchi S; Faculty of Pharmaceutical Sciences, Toho University. |
| المصدر: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2024; Vol. 72 (5), pp. 480-486. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN: 1347-5223 (Electronic) Linking ISSN: 00092363 NLM ISO Abbreviation: Chem Pharm Bull (Tokyo) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Tokyo, Pharmaceutical Society of Japan. |
| مواضيع طبية MeSH: |
X-Ray Absorption Spectroscopy* , Diphosphonates*/chemistry, Phosphorus/chemistry ; Crystallization ; Molecular Structure |
| مستخلص: |
X-ray absorption near-edge structure (XANES) spectroscopy is a new method for the characterization of active pharmaceutical ingredients. XANES spectra show unique features depending on the electronic states of the X-ray absorbing elements and provide information about the chemical environment that affects the electronic states. In this study, six bisphosphonate hydrate crystals were used to investigate, for the first time, how the phosphorus K-edge XANES spectra are affected by the interatomic interactions and charged states of phosphonate moieties. Phosphorus K-edge XANES spectra showed several differences among the bisphosphonates. In particular, the chlorine atoms covalently bonded near the phosphonate and the number of electric charges of the phosphonate moieties seemed to have large effects on peak shape in XANES spectra. Unique shapes of the XANES spectra demonstrated that differences in interactions at the oxygen atoms of the phosphonate moieties could change the shapes of the XANES spectrum peaks to the extent that each material was distinguished based on the spectra. Since slight differences in interatomic interactions and charged states lead to variations in the spectra, XANES spectroscopy could be widely applied as the fingerprint method to evaluate active pharmaceutical ingredients. |
| فهرسة مساهمة: |
Keywords: X-ray absorption near-edge structure spectroscopy; bisphosphonate; crystal structure |
| تواريخ الأحداث: |
Date Created: 20240519 Date Completed: 20240519 Latest Revision: 20240519 |
| رمز التحديث: |
20240520 |
| DOI: |
10.1248/cpb.c24-00148 |
| PMID: |
38763752 |
| قاعدة البيانات: |
MEDLINE |
