دورية أكاديمية
أعرض في EDS

Viability assessment of the liver during ex-situ machine perfusion prior to transplantation.

التفاصيل البيبلوغرافية
العنوان: Viability assessment of the liver during ex-situ machine perfusion prior to transplantation.
المؤلفون: Groen PC; Department of Surgery, Division of Hepato-Pancreato- Biliary and Transplant Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., van Leeuwen OB, de Jonge J, Porte RJ
المصدر: Current opinion in organ transplantation [Curr Opin Organ Transplant] 2024 Aug 01; Vol. 29 (4), pp. 239-247. Date of Electronic Publication: 2024 May 17.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9717388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-7013 (Electronic) Linking ISSN: 10872418 NLM ISO Abbreviation: Curr Opin Organ Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Philadelphia, PA : Rapid Science Publishers,
مواضيع طبية MeSH: Perfusion*/methods , Perfusion*/adverse effects , Liver Transplantation*/adverse effects , Liver*/surgery , Liver*/metabolism , Organ Preservation*/methods , Organ Preservation*/adverse effects, Humans ; Tissue Survival ; Tissue Donors ; Hepatocytes/metabolism ; Hepatocytes/transplantation ; Animals ; Donor Selection ; Bile/metabolism ; Cell Survival ; Biomarkers/metabolism ; Predictive Value of Tests ; Cold Ischemia/adverse effects
مستخلص: Purpose of Review: In an attempt to reduce waiting list mortality in liver transplantation, less-than-ideal quality donor livers from extended criteria donors are increasingly accepted. Predicting the outcome of these organs remains a challenge. Machine perfusion provides the unique possibility to assess donor liver viability pretransplantation and predict postreperfusion organ function.
Recent Findings: Assessing liver viability during hypothermic machine perfusion remains challenging, as the liver is not metabolically active. Nevertheless, the levels of flavin mononucleotide, transaminases, lactate dehydrogenase, glucose and pH in the perfusate have proven to be predictors of liver viability. During normothermic machine perfusion, the liver is metabolically active and in addition to the perfusate levels of pH, transaminases, glucose and lactate, the production of bile is a crucial criterion for hepatocyte viability. Cholangiocyte viability can be determined by analyzing bile composition. The differences between perfusate and bile levels of pH, bicarbonate and glucose are good predictors of freedom from ischemic cholangiopathy.
Summary: Although consensus is lacking regarding precise cut-off values during machine perfusion, there is general consensus on the importance of evaluating both hepatocyte and cholangiocyte compartments. The challenge is to reach consensus for increased organ utilization, while at the same time pushing the boundaries by expanding the possibilities for viability testing.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
References: Biomedicines. 2021 Feb 07;9(2):. (PMID: 33562406)
Sci Rep. 2016 Feb 24;6:22107. (PMID: 26905693)
Transplant Proc. 1997 Feb-Mar;29(1-2):412-5. (PMID: 9123060)
Liver Transpl. 2019 Jun;25(6):848-858. (PMID: 30938039)
J Surg Res. 2019 Mar;235:383-394. (PMID: 30691820)
Ann Transplant. 2020 Apr 21;25:e921529. (PMID: 32312947)
EBioMedicine. 2020 Oct;60:103014. (PMID: 32979838)
J Hepatol. 2006 Oct;45(4):484-8. (PMID: 16905221)
Ann Surg. 2011 Apr;253(4):817-25. (PMID: 21475025)
Transplant Proc. 2012 Nov;44(9):2868-73. (PMID: 23146544)
Am J Transplant. 2016 Nov;16(11):3235-3245. (PMID: 27192971)
J Hepatol. 2018 Mar;68(3):456-464. (PMID: 29155020)
Liver Transpl. 2018 Oct;24(10):1453-1469. (PMID: 30359490)
Transplantation. 2020 Sep;104(9):1929-1942. (PMID: 32769628)
Transplantation. 2019 Jan;103(1):78-90. (PMID: 30418431)
PLoS One. 2014 Nov 04;9(11):e110642. (PMID: 25369327)
EBioMedicine. 2023 Dec;98:104857. (PMID: 37918219)
Liver Transpl. 2018 Dec;24(12):1699-1715. (PMID: 30058119)
Shock. 2012 Feb;37(2):234-8. (PMID: 22089187)
Hepatol Int. 2020 Dec;14(6):1075-1082. (PMID: 33278022)
Am J Nucl Med Mol Imaging. 2021 Aug 15;11(4):233-249. (PMID: 34513277)
Nat Commun. 2020 Jun 16;11(1):2939. (PMID: 32546694)
Thromb Res. 2023 Aug;228:64-71. (PMID: 37290373)
Sci Rep. 2021 Dec 6;11(1):23444. (PMID: 34873187)
Am J Transplant. 2007 May;7(5):1265-70. (PMID: 17359503)
Transplantation. 2017 Jul;101(7):1542-1550. (PMID: 28060242)
Clin Transplant. 2020 Mar;34(3):e13790. (PMID: 31984571)
Transplantation. 2017 May;101(5):1084-1098. (PMID: 28437389)
Transplantation. 2017 Feb;101(2):e42-e48. (PMID: 27941437)
Liver Int. 2015 Jan;35(1):156-63. (PMID: 24351095)
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1507-1515. (PMID: 28645651)
Liver Int. 2015 Apr;35(4):1172-84. (PMID: 25039534)
Nat Biotechnol. 2020 Feb;38(2):189-198. (PMID: 31932726)
Compr Physiol. 2014 Jan;4(1):177-97. (PMID: 24692138)
Transplantation. 2021 Apr 1;105(4):796-815. (PMID: 33760791)
Liver Transpl. 2020 Dec;26(12):1618-1628. (PMID: 32682340)
Nucl Med Commun. 2021 Jul 1;42(7):826-832. (PMID: 33741853)
Am J Transplant. 2022 Jun;22(6):1658-1670. (PMID: 35286759)
Artif Organs. 2024 May;48(5):472-483. (PMID: 38132848)
Ann Surg. 2019 Nov;270(5):906-914. (PMID: 31633615)
Am J Transplant. 2019 Apr;19(4):1202-1211. (PMID: 30588774)
Liver Transpl. 2020 Sep;26(9):1177-1187. (PMID: 32246581)
Liver Transpl. 2012 Dec;18(12):1495-507. (PMID: 22987314)
Anesthesiology. 1968 Nov-Dec;29(6):1107-12. (PMID: 5726746)
Ann Surg. 2019 Nov;270(5):783-790. (PMID: 31592808)
Transplantation. 2019 Jul;103(7):1405-1413. (PMID: 30395120)
Transplantation. 2022 Apr 1;106(4):792-805. (PMID: 34144552)
Liver Transpl. 2019 Oct;25(10):1503-1513. (PMID: 31206217)
Am J Transplant. 2013 May;13(5):1327-35. (PMID: 23463950)
Transplantation. 2020 Sep;104(9):1917-1928. (PMID: 32371845)
Liver Transpl. 2016 Aug;22(8):1107-14. (PMID: 27028896)
Am J Transplant. 2018 Aug;18(8):2005-2020. (PMID: 29419931)
Surgery. 2022 Mar;171(3):747-756. (PMID: 35065791)
Updates Surg. 2022 Feb;74(1):193-202. (PMID: 34542843)
Liver Transpl. 2014 Nov;20(11):1372-82. (PMID: 25046819)
Am J Transplant. 2021 Feb;21 Suppl 2:521-558. (PMID: 33595189)
Artif Organs. 2023 Feb;47(2):317-329. (PMID: 36106378)
Transplant Direct. 2022 Nov 17;8(12):e1420. (PMID: 36406899)
Nature. 2018 May;557(7703):50-56. (PMID: 29670285)
Transpl Int. 2022 May 16;35:10355. (PMID: 35651880)
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240520 Date Completed: 20240702 Latest Revision: 20240707
رمز التحديث: 20240707
مُعرف محوري في PubMed: PMC11224566
DOI: 10.1097/MOT.0000000000001152
PMID: 38764406
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-7013
DOI:10.1097/MOT.0000000000001152