دورية أكاديمية
أعرض في EDS

Diosmin protects the testicles from doxorubicin-induced damage by increasing steroidogenesis and suppressing oxido-inflammation and apoptotic mediators.

التفاصيل البيبلوغرافية
العنوان: Diosmin protects the testicles from doxorubicin-induced damage by increasing steroidogenesis and suppressing oxido-inflammation and apoptotic mediators.
المؤلفون: Oyovwi MO; Department of Physiology, Adeleke University Ede, Osun State, Nigeria.; Department of Hunan Physiology, Achievers University Owo, Ondo State, Nigeria., Ben-Azu B; DELSU Joint Canada-Israel Neuroscience and Biopsychiatry, Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University Abraka, Delta State, Nigeria., Tesi EP; Department of Science Laboratory Technology, Delta State Polytechnic Ogwashi-Uku, Delta State, Nigeria., Ojetola AA; Department of Physiology, Adeleke University Ede, Osun State, Nigeria., Olowe TG; Department of Physiology, University of Medical Sciences Ondo, Ondo State, Nigeria., Joseph UG; Department of Medical Laboratory Science, Adeleke University Ede, Osun State, Nigeria., Emojevwe V; Department of Physiology, University of Medical Sciences Ondo, Ondo State, Nigeria., Oghenetega OB; Department of Physiology, School of Basic Medical Science, Babcock University Illisan, Ogun State, Nigeria., Rotu RA; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, University of Ibadan Ibadan, Oyo State, Nigeria., Rotu RA; Department of Industrial Safety and Environmental Management, School of Maritime Technology Burutu, Delta State, Nigeria., Falajiki FY; Department of Physiology, Adeleke University Ede, Osun State, Nigeria.
المصدر: International journal of biochemistry and molecular biology [Int J Biochem Mol Biol] 2024 Apr 15; Vol. 15 (2), pp. 34-50. Date of Electronic Publication: 2024 Apr 15 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101532076 Publication Model: eCollection Cited Medium: Print ISSN: 2152-4114 (Print) Linking ISSN: 21524114 NLM ISO Abbreviation: Int J Biochem Mol Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Madison, Wis. : e-Century Pub. Corp.
مستخلص: Background: Cancer chemotherapy with doxorubicin (DOX) has been linked to serious testicular damage and spermatotoxicity due to the induction of oxidative stress, inflammation, and apoptosis. Thus, the current study was carried out to assess the potential ameliorative impact of diosmin, an antioxidant drug, against DOX-mediated spermatoxicity and testicular injury in rats.
Material and Methods: In the experimental protocol, rats were grouped into 4: Group 1 received vehicle and saline for 8 weeks while group 2 received diosmin and saline concomitantly for 8 weeks. Group 3 was given 3 mg/kg intraperitoneal DOX once every 7 days for 8 weeks. Group 4 was given 40 mg/kg of diosmin orally for 56 days followed by DOX diosmin administration after one hour. After 56 days of treatment, sperm quality, hormonal testing, biochemical parameters, and histological alterations in the testes were evaluated.
Results: DOX-induced reduce spermatogenic function, testicular 3- and 17β-Hydroxysteroid dehydrogenases, and serum follicle stimulating hormone, luteinizing hormone, and testosterone. It also enhanced inflammation, testicular oxidative damage, and apoptosis. The histopathologic examinations corroborated the biochemical results obtained. Significantly, diosmin treatment reduced DOX-induced injury, as evidenced by restored testicular architecture, increased steroidogenesis, preservation of spermatogenesis, suppression of oxide-inflammatory response, and apoptosis.
Conclusion: It was found that through diosmin antioxidant, anti-apoptotic, and anti-oxido-inflammatory it presents a possible therapeutic alternative for protecting testicular tissue against DOX's harmful effects.
Competing Interests: None.
(IJBMB Copyright © 2024.)
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فهرسة مساهمة: Keywords: Gonadotoxicity; apoptosis; diosmin; doxorubicin; inflammation; oxidative stress; spermatoxicity
تواريخ الأحداث: Date Created: 20240520 Latest Revision: 20240521
رمز التحديث: 20240521
مُعرف محوري في PubMed: PMC11101964
DOI: 10.62347/ORPK5021
PMID: 38765875
قاعدة البيانات: MEDLINE
الوصف
تدمد:2152-4114
DOI:10.62347/ORPK5021