التفاصيل البيبلوغرافية
| العنوان: |
Eubacterium rectale detoxification mechanism increases resilience of the gut environment. |
| المؤلفون: |
Richie TG, Wiechman H, Ingold C, Heeren L, Kamke A, Pogranichniy S, Monk K, Summers T, Ran Q, Sarkar S, Plattner BL, Sidebottom AM, Chang E, Lee STM |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 May 09. Date of Electronic Publication: 2024 May 09. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Lachnospiraceae members were highly detected in dysbiotic IL-10 KO mice that displayed similar physiological outcomes as control mice. Lachnospiraceae is a highly diverse family of microbes that have been shown to display both commensal and pathogenic characteristics in the colon environment. We investigated the impact of genetic variation in five Lachnospiraceae strains on lowering cellular inflammation and ROS levels. Cell free spent media (CFSM) from Eubacterium rectale resulted in lowered ROS, and nitric oxide levels in stressed colon cells. We demonstrated through an array of multi-omics and molecular techniques that glutathione (GSH) biosynthesized by E. rectale was able to alleviate host ROS damage. We further showed downregulation of cell stress and immune response genes by host RNA sequencing, which is evidence that E. rectale microbial products promote recovery and alleviate ROS stress. |
| تواريخ الأحداث: |
Date Created: 20240520 Latest Revision: 20240520 |
| رمز التحديث: |
20240520 |
| مُعرف محوري في PubMed: |
PMC11100834 |
| DOI: |
10.1101/2024.05.09.593360 |
| PMID: |
38766022 |
| قاعدة البيانات: |
MEDLINE |
