دورية أكاديمية
Exogenous ketone esters as a potential therapeutic for treatment of sarcopenic obesity.
| العنوان: | Exogenous ketone esters as a potential therapeutic for treatment of sarcopenic obesity. |
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| المؤلفون: | Deemer SE; Department of Kinesiology, Health Promotion & Recreation, University of North Texas, Denton, Texas, United States., Roberts BM; US Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts, United States., Smith DL; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States., Plaisance EP; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States., Philp A; Centre for Healthy Ageing, Centenary Institute, Sydney, New South Wales, Australia.; School of Sport, Exercise and Rehabilitation Sciences, University of Technology Sydney, Sydney, New South Wales, Australia. |
| المصدر: | American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Jul 01; Vol. 327 (1), pp. C140-C150. Date of Electronic Publication: 2024 May 20. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society, |
| مواضيع طبية MeSH: | Sarcopenia*/metabolism , Sarcopenia*/drug therapy , Sarcopenia*/diet therapy , Obesity*/metabolism , Obesity*/drug therapy , Ketones*/metabolism , Diet, Ketogenic*/methods , Esters* , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/drug effects, Humans ; Animals |
| مستخلص: | Identifying effective treatment(s) for sarcopenia and sarcopenic obesity is of paramount importance as the global population advances in age and obesity continues to be a worldwide concern. Evidence has shown that a ketogenic diet can be beneficial for the preservation of muscle quality and function in older adults, but long-term adherence is low due in part to the high-fat (≥80%), very low carbohydrate (<5%) composition of the diet. When provided in adequate amounts, exogenous ketone esters (KEs) can increase circulating ketones to concentrations that exceed those observed during prolonged fasting or starvation without significant alterations in the diet. Ketone esters first emerged in the mid-1990s and their use in preclinical and clinical research has escalated within the past 10-15 years. We present findings from a narrative review of the existing literature for a proposed hypothesis on the effects of exogenous ketones as a therapeutic for preservation of skeletal muscle and function within the context of sarcopenic obesity and future directions for exploration. Much of the reviewed literature herein examines the mechanisms of the ketone diester ( R , S -1,3-butanediol diacetoacetate) on skeletal muscle mass, muscle protein synthesis, and epigenetic regulation in murine models. Additional studies are needed to further examine the key regulatory factors producing these effects in skeletal muscle, examine convergent and divergent effects among different ketone ester formulations, and establish optimal frequency and dosing regimens to translate these findings into humans. |
| فهرسة مساهمة: | Keywords: aging; ketone diester; ketone monoester; obesity; sarcopenia |
| المشرفين على المادة: | 0 (Ketones) 0 (Esters) |
| تواريخ الأحداث: | Date Created: 20240520 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1152/ajpcell.00471.2023 |
| PMID: | 38766768 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1563 |
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| DOI: | 10.1152/ajpcell.00471.2023 |