دورية أكاديمية
أعرض في EDS

Bed rest impairs the vestibular control of balance.

التفاصيل البيبلوغرافية
العنوان: Bed rest impairs the vestibular control of balance.
المؤلفون: Mackenzie SW; School of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Birmingham, UK., Smith CP; School of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Birmingham, UK., Tremblay MF; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada., Day BL; Department of Clinical and Movement Neurosciences, University College London, London, UK., Reynolds RF; School of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
المصدر: The Journal of physiology [J Physiol] 2024 Jun; Vol. 602 (12), pp. 2985-2998. Date of Electronic Publication: 2024 May 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell : Cambridge Univ. Press
Original Publication: London, Cambridge Univ. Press.
مواضيع طبية MeSH: Bed Rest* , Postural Balance*/physiology , Vestibule, Labyrinth*/physiology, Humans ; Male ; Adult ; Young Adult
مستخلص: Prolonged bed rest impairs standing balance but the underlying mechanisms are uncertain. Previous research suggests strength loss is not the cause, leaving impaired sensorimotor control as an alternative. Here we examine vestibular control of posture in 18 male volunteers before and after 60 days of bed rest. Stochastic vestibular stimulation (SVS) was used to evoke sway responses before, 1 and 6 days after bed rest under different head yaw orientations. The directional accuracy and precision of these responses were calculated from ground reaction force vectors. Bed rest caused up to 63% increases in spontaneous standing sway and 31% reductions in leg strength, changes which were uncorrelated. The increase in sway was exacerbated when the eyes were closed. Mean directions of SVS-evoked sway responses were unaffected, being directed towards the anodal ear and rotating in line with head orientation in the same way before and after bed rest. However, individual trial analysis revealed 25%-30% increases in directional variability, which were significantly correlated with the increase in spontaneous sway (r = 0.48-0.71; P ≤ 0.044) and were still elevated on day 6 post-bed rest. This reveals that individual sway responses may be inappropriately oriented, a finding masked by the averaging process. Our results confirm that impaired balance following prolonged bedrest is not related to loss of strength. Rather, they demonstrate that the sensorimotor transformation process which converts vestibular feedback into appropriately directed balance responses is impaired. KEY POINTS: Prolonged inactivity impairs balance but previous research suggests this is not caused by loss of strength. Here we investigated vestibular control of balance before and after 60 days of bed rest using electrical vestibular stimulation (EVS) to evoke sway responses. Spontaneous sway significantly increased and muscle strength reduced following bed rest, but, in keeping with previous research, these two effects were not correlated. While the overall accuracy of EVS-evoked sway responses was unaffected, their directional variability significantly increased following bed rest, and this was correlated with the increases in spontaneous sway. We have shown that the ability to transform head-centred vestibular feedback into an appropriately directed body sway response is negatively affected by prolonged inactivity; this may contribute to the impaired balance commonly observed following bed rest.
(© 2024 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
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معلومات مُعتمدة: BB/P017185/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
فهرسة مساهمة: Keywords: accuracy; bed rest; electrical vestibular stimulation; precision; proprioceptive acuity
تواريخ الأحداث: Date Created: 20240520 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1113/JP285834
PMID: 38766932
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-7793
DOI:10.1113/JP285834