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Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis.

التفاصيل البيبلوغرافية
العنوان: Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis.
المؤلفون: da Silva DD; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Frederico FB; Hospital de Base of the Regional Medical Faculty Foundation (HB-FUNFARME), Ophthalmology Outpatient Clinic, São José do Rio Preto, Brazil., Previato M; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Siqueira RC; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Bonini-Domingos CR; Department of Biology, São Paulo State University 'Júlio de Mesquita Filho' (UNESP), São José do Rio Preto, Brazil., de Souza VH; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Maringá, Brazil., Castiglioni L; Department of Epidemiology and Collective Health, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Brandão CC; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., de Mattos LC; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Ayo CM; Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.
المصدر: Parasite immunology [Parasite Immunol] 2024 May; Vol. 46 (5), pp. e13038.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7910948 Publication Model: Print Cited Medium: Internet ISSN: 1365-3024 (Electronic) Linking ISSN: 01419838 NLM ISO Abbreviation: Parasite Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Wiley
مواضيع طبية MeSH: Toxoplasmosis, Ocular*/genetics , Toxoplasmosis, Ocular*/immunology , Toxoplasmosis, Ocular*/parasitology , Interleukin-17*/genetics, Humans ; Male ; Female ; Adult ; Brazil ; Middle Aged ; Young Adult ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Polymorphism, Restriction Fragment Length ; Protective Factors ; Adolescent ; Genotype ; Polymorphism, Genetic ; Polymerase Chain Reaction ; Aged
مستخلص: Ocular toxoplasmosis (OT) is characterised by intraocular inflammation due to Toxoplasma gondii infection. Studies have found that interleukin 17 (IL-17) plays a central role in the pathology of OT. However, nucleotide variability in IL17 and interleukin 17 receptor (IL17R) genes has not been characterised in OT. As cytokine gene polymorphisms may influence the expression of these molecules, the aim of this study was to verify whether IL17A (rs2275913), IL17F (rs763780), IL17RA (rs4819554) and IL17RC (rs708567) polymorphisms are associated with OT in a Brazilian population. This study enrolled 214 patients seropositive for T. gondii (110 with OT and 104 without) and 107 controls. Polymorphisms were identified by PCR-restriction fragment length polymorphism analysis, validated by DNA sequencing with chi-square and multivariate analyses being used to assess possible associations between polymorphisms and OT. Logistic regression under the dominant model revealed a protection factor against OT of the C mutant allele of the IL17F (rs763780) polymorphism. The T/C-C/C genotypes were significantly more common in patients without OT compared to those with OT (p value = 0.0066) and controls (p value = 0.014). Findings from this study suggest that the IL17F polymorphism may have an influence in the immunopathology of OT in Brazilian individuals.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 09/2022 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2013/25650-8 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2013/06580-9 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2013/10050-5 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: Toxoplasma gondii; cytokine; interleukin 17; ocular toxoplasmosis; polymorphism
المشرفين على المادة: 0 (IL17F protein, human)
تواريخ الأحداث: Date Created: 20240520 Date Completed: 20240520 Latest Revision: 20240520
رمز التحديث: 20240520
DOI: 10.1111/pim.13038
PMID: 38767154
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-3024
DOI:10.1111/pim.13038