دورية أكاديمية
HT-2 mycotoxin and selenium deficiency: Effects on Femur development and integrity in Young mice.
| العنوان: | HT-2 mycotoxin and selenium deficiency: Effects on Femur development and integrity in Young mice. |
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| المؤلفون: | Hao S; Department of Orthopaedics, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Yao C; Nursing Department, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Meng P; Department of Orthopaedics, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Jia Y; Department of Orthopaedics, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Li L; Department of Orthopaedics, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Zhang C; Department of Orthopaedics, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. Electronic address: zyt1117@126.com., Guo X; School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People's Republic of China, Xi'an 710061, Shaanxi, China. Electronic address: guox@xjtu.edu.cn. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Jul; Vol. 245, pp. 107767. Date of Electronic Publication: 2024 May 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Selenium*/deficiency , Femur* , T-2 Toxin*/toxicity, Animals ; Mice ; Male ; Kashin-Beck Disease ; X-Ray Microtomography |
| مستخلص: | Kashin-Beck Disease (KBD), an osteoarticular disorder, is potentially influenced by several factors, among which selenium deficiency and HT-2 mycotoxin exposure are considered significant. However, the combined effect of these factors on femoral development remains unclear, Conducted over eight weeks on forty-eight male mice categorized into control, selenium-deficient, and HT-2 toxin-exposed groups, including dual-exposure sets, this study comprehensively monitored body weight, bone metabolism markers, and cellular health. Employing biomechanical analysis, micro-computed tomography (micro-CT), and transmission electron microscopy (TEM), we unearthed a reduction in body weight due to HT-2 toxin alone, with selenium deficiency exacerbating these effects synergistically. Our results unveil that both factors independently affect bone metabolism, yet their confluence leads to a pronounced degradation of bone health parameters, including alterations in calcium, phosphorus, and vitamin D levels, alongside marked changes in osteoblast and osteoclast activity and bone cell structures. The notable damage to femoral cortical and trabecular architectures underscores the perilous interplay between dietary selenium absence and HT-2 toxin presence, necessitating a deeper understanding of their separate and joint effects on bone integrity. These discoveries underscore the imperative for a nuanced approach to toxicology research and public health policy, highlighting the pivotal influence of environmental and nutritional factors on skeletal well-being. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bone quality; Deoxynivalenol; Mycotoxin ratios; Skeletal toxicology; Spinal growth; T-2 mycotoxin |
| المشرفين على المادة: | H6241UJ22B (Selenium) I3FL5NM3MO (T-2 Toxin) |
| تواريخ الأحداث: | Date Created: 20240520 Date Completed: 20240616 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1016/j.toxicon.2024.107767 |
| PMID: | 38768830 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
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| DOI: | 10.1016/j.toxicon.2024.107767 |