دورية أكاديمية
Preoperative blood urea nitrogen-to-serum albumin ratio for prediction of in-hospital mortality in patients who underwent emergency surgery for acute type A aortic dissection.
| العنوان: | Preoperative blood urea nitrogen-to-serum albumin ratio for prediction of in-hospital mortality in patients who underwent emergency surgery for acute type A aortic dissection. |
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| المؤلفون: | Wu Q; Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, P. R. China.; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, 350001, P. R. China., Zheng J; Department of Pharmacy, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, P. R. China., Lin J; Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, P. R. China., Xie L; Fujian Medical University, Fuzhou, Fujian, P. R. China., Tang M; Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, P. R. China., Ke M; Department of Pharmacy, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, P. R. China. 1012899907@qq.com., Chen L; Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, P. R. China. chenliangwan@tom.com.; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, 350001, P. R. China. chenliangwan@tom.com. |
| المصدر: | Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Jul; Vol. 47 (7), pp. 1934-1942. Date of Electronic Publication: 2024 May 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : London : Nature Publishing Group Original Publication: Toyonaka, Japan : The Society, c1992-2003 |
| مواضيع طبية MeSH: | Aortic Dissection*/surgery , Aortic Dissection*/blood , Aortic Dissection*/mortality , Hospital Mortality* , Blood Urea Nitrogen*, Humans ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Serum Albumin/analysis ; Prognosis ; Predictive Value of Tests ; Adult ; Preoperative Period |
| مستخلص: | The study aimed to assess the predictive value of blood urea nitrogen (BUN)-to-albumin ratio (BA-R) for in-hospital mortality in patients undergoing emergency surgery for acute type A aortic dissection (ATAAD). Patients who were diagnosed with ATAAD and underwent emergency surgery within 48 hours of onset at our hospital between January 2015 and December 2021 were included in this study. The primary endpoint of this study was postoperative in-hospital mortality (POIM). The data of the survivors and non-survivors were retrospectively compared analyses. A total of 557 ATAAD patients were included, with 505 survivors and 52 non-survivors. The preoperative BA-R of the non-survivor group was significantly higher than that of the survivor group (P < 0.001). Univariate regression analysis showed that preoperative BA-R, serum creatinine level, SA level, D-dimer level, age, myocardial ischemia, cerebral ischemia, and aortic clamp time were risk factors for POIM. In addition, multivariable regression analysis showed that preoperative BA-R ≥ 0.155 mmol/g was a risk factor for POIM (odds ratio, 6.815 [3.582-12.964]; P < 0.001). Receiver operating characteristic curve indicated that the cut-off point for preoperative BA-R was ≥0.155 mmol/g (area under the curve =0.874). The sensitivity and specificity of preoperative BA-R in predicting the POIM of patients who underwent emergency surgery for ATAAD were 84.6% and 71.3%, respectively (95% confidence interval, 0.829-0.919; P < 0.001). In conclusion, Preoperative BA-R is a simple, rapid, and potentially useful prognostic indicator of POIM in patients with ATAAD. BAR: Blood urea nitrogen-to-albumin ratio, BUN: Blood urea nitrogen, SA: Serum albumin, REF: Reference. The aim of this study was to evaluate the prognostic value of BA-R for the prediction of postoperative in-hospital mortality in patients who underwent emergency surgery for ATAAD. A total of 557 patients with ATAAD were enrolled, and 505 survived while 52 did not. The preoperative BA-R of the non-survivor group was significantly higher than that of the survivor group (0.27 [0.18, 0.46] vs. 0.12 [0.10, 0.16]mmol/g; P < 0.001). The study showed that preoperative BA-R ≥ 0.155 mmol/g was a risk factor for POIM (odds ratio, 6.815 [3.582-12.964]; P < 0.001). ROC curve indicated that the cut-off point for preoperative BA-R was ≥0.155 mmol/g (AUC = 0.874) and the sensitivity and specificity were 84.6% and 71.3%, respectively (95% CI, 0.829-0.919; P < 0.001). We believe that our study makes a significant contribution to the literature because we found preoperative BA-R to be a simple, rapid, and potentially useful prognostic indicator of postoperative in-hospital mortality in patients with ATAAD. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Acute type A aortic dissection; Blood urea nitrogen-to-serum albumin ratio; Emergency surgery; Postoperative in-hospital mortality; Prognostic ability |
| المشرفين على المادة: | 0 (Serum Albumin) |
| تواريخ الأحداث: | Date Created: 20240520 Date Completed: 20240704 Latest Revision: 20240716 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC11224014 |
| DOI: | 10.1038/s41440-024-01673-z |
| PMID: | 38769137 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1348-4214 |
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| DOI: | 10.1038/s41440-024-01673-z |