دورية أكاديمية
Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality.
| العنوان: | Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality. |
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| المؤلفون: | Chander A; Department of Veterinary & Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.; Department of Veterinary and Animal Sciences, University of Massachusetts- Amherst, 661 North Pleasant Street, Amherst, Massachusetts, USA., Mager J; Department of Veterinary & Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.; Department of Veterinary and Animal Sciences, University of Massachusetts- Amherst, 661 North Pleasant Street, Amherst, Massachusetts, USA. |
| المصدر: | Molecular reproduction and development [Mol Reprod Dev] 2024 May; Vol. 91 (5), pp. e23760. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8903333 Publication Model: Print Cited Medium: Internet ISSN: 1098-2795 (Electronic) Linking ISSN: 1040452X NLM ISO Abbreviation: Mol Reprod Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, N.J. : Wiley-Liss Original Publication: New York, NY : A.R. Liss, 1988- |
| مواضيع طبية MeSH: | Embryonic Development*/genetics, Animals ; Female ; Mice ; Blastocyst/metabolism ; Blastocyst/cytology ; Blastocyst Inner Cell Mass/metabolism ; Blastocyst Inner Cell Mass/cytology ; Embryo Loss/pathology ; Embryo Loss/genetics ; Embryo Loss/metabolism ; Histone Acetyltransferases/metabolism ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/deficiency ; Mice, Knockout |
| مستخلص: | e-Lysine acetylation is a prominent histone mark found at transcriptionally active loci. Among many lysine acetyl transferases, nonspecific lethal complex (NSL) members are known to mediate the modification of histone H4. In addition to histone modifications, the KAT8 regulatory complex subunit 3 gene (Kansl3), a core member of NSL complex, has been shown to be involved in several other cellular processes such as mitosis and mitochondrial activity. Although functional studies have been performed on NSL complex members, none of the four core proteins, including Kansl3, have been studied during early mouse development. Here we show that homozygous knockout Kansl3 embryos are lethal at peri-implantation stages, failing to hatch out of the zona pellucida. When the zona pellucida is removed in vitro, Kansl3 null embryos form an abnormal outgrowth with significantly disrupted inner cell mass (ICM) morphology. We document lineage-specific defects at the blastocyst stage with significantly reduced ICM cell number but no difference in trophectoderm cell numbers. Both epiblast and primitive endoderm lineages are altered with reduced cell numbers in null mutants. These results show that Kansl3 is indispensable during early mouse embryonic development and with defects in both ICM and trophectoderm lineages. (© 2024 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | R01 HD083311 United States HD NICHD NIH HHS; United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: Kansl3; blastocyst; epigenetic regulation; histone modification; inner cell mass; preimplantation |
| المشرفين على المادة: | EC 2.3.1.48 (Histone Acetyltransferases) |
| تواريخ الأحداث: | Date Created: 20240521 Date Completed: 20240521 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| مُعرف محوري في PubMed: | PMC11244731 |
| DOI: | 10.1002/mrd.23760 |
| PMID: | 38769918 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-2795 |
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| DOI: | 10.1002/mrd.23760 |