دورية أكاديمية
Self-Healing Guar Gum-Based Nanocomposite Hydrogel Promotes Infected Wound Healing through Photothermal Antibacterial Therapy.
| العنوان: | Self-Healing Guar Gum-Based Nanocomposite Hydrogel Promotes Infected Wound Healing through Photothermal Antibacterial Therapy. |
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| المؤلفون: | Yang W; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Zhang Q; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Zhou J; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Li L; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang 315302, China., Li Y; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang 315302, China., Zhu L; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China., Narain R; Department of Chemical and Materials Engineering, College of Natural and Applied Sciences, University of Alberta, Edmonton, Alberta T6G 2G6, Canada., Nan K; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang 315302, China., Chen Y; National Engineering Research Center of Ophthalmology and Optometry, Institute of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang 315302, China. |
| المصدر: | Biomacromolecules [Biomacromolecules] 2024 Jun 10; Vol. 25 (6), pp. 3432-3448. Date of Electronic Publication: 2024 May 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2000- |
| مواضيع طبية MeSH: | Mannans*/chemistry , Mannans*/pharmacology , Plant Gums*/chemistry , Plant Gums*/pharmacology , Galactans*/chemistry , Galactans*/pharmacology , Wound Healing*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Nanocomposites*/chemistry , Hydrogels*/chemistry , Hydrogels*/pharmacology , Photothermal Therapy*/methods, Animals ; Mice ; Tannins/chemistry ; Tannins/pharmacology ; Staphylococcus aureus/drug effects ; Humans ; Escherichia coli/drug effects ; Borates |
| مستخلص: | Preventing bacterial infections is a crucial aspect of wound healing. There is an urgent need for multifunctional biomaterials without antibiotics to promote wound healing. In this study, we fabricated a guar gum (GG)-based nanocomposite hydrogel, termed GBTF, which exhibited photothermal antibacterial therapy for infected wound healing. The GBTF hydrogel formed a cross-linked network through dynamic borate/diol interactions between GG and borax, thereby exhibiting simultaneously self-healing, adaptable, and injectable properties. Additionally, tannic acid (TA)/Fe 3+ nanocomplexes (NCs) were incorporated into the hydrogel to confer photothermal antibacterial properties. Under the irradiation of an 808 nm near-infrared laser, the TA/Fe 3+ NCs in the hydrogel could rapidly generate heat, leading to the disruption of bacterial cell membranes and subsequent bacterial eradication. Furthermore, the hydrogels exhibited good cytocompatibility and hemocompatibility, making them a precandidate for preclinical and clinical applications. Finally, they could significantly promote bacteria-infected wound healing by reducing bacterial viability, accelerating collagen deposition, and promoting epithelial remodeling. Therefore, the multifunctional GBTF hydrogel, which was composed entirely of natural substances including guar gum, borax, and polyphenol/ferric ion NCs, showed great potential for regenerating infected skin wounds in clinical applications. |
| المشرفين على المادة: | 0 (Mannans) 0 (Plant Gums) 0 (Galactans) E89I1637KE (guar gum) 0 (Anti-Bacterial Agents) 0 (Hydrogels) 0 (Tannins) 1303-96-4 (borax) 0 (Borates) |
| تواريخ الأحداث: | Date Created: 20240521 Date Completed: 20240610 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1021/acs.biomac.4c00080 |
| PMID: | 38771294 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1526-4602 |
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| DOI: | 10.1021/acs.biomac.4c00080 |