التفاصيل البيبلوغرافية
| العنوان: |
Pragmaticism in Cancer Clinical Trials. |
| المؤلفون: |
Sankar K; Cedars-Sinai Medical Center, Los Angeles, CA., Redman MW; SWOG Statistics and Data Management Center, Seattle, WA.; Fred Hutchinson Cancer Center, Seattle, WA., Dragnev KH; Dartmouth Hitchcock Medical Center, Lebanon, NH., Henick BS; Columbia University/Herbert Irving Comprehensive Cancer Center, New York, NY., Iams WT; Vanderbilt University Medical Center, Nashville, TN., Blanke CD; SWOG Network Operations Center/Oregon Health & Science University, Portland, OR., Herbst RS; Yale University, New Haven, CT., Gray JE; Moffitt Cancer Center, Tampa, FL., Reckamp KL; Cedars-Sinai Medical Center, Los Angeles, CA. |
| المصدر: |
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting [Am Soc Clin Oncol Educ Book] 2024 Jun; Vol. 44 (3), pp. e100040. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101233985 Publication Model: Print Cited Medium: Internet ISSN: 1548-8756 (Electronic) Linking ISSN: 15488748 NLM ISO Abbreviation: Am Soc Clin Oncol Educ Book Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Alexandria, Va. : American Society of Clinical Oncology |
| مواضيع طبية MeSH: |
Neoplasms*/therapy , Clinical Trials as Topic*, Humans ; Research Design ; Pragmatic Clinical Trials as Topic/methods ; Medical Oncology/methods |
| مستخلص: |
Clinical trials are essential for advancing oncology treatment strategies and have contributed significantly to the decline in cancer mortality rates over the past decades. Traditional explanatory trials, focused on establishing intervention efficacy in ideal settings, often lack generalizability and may not reflect real-world patient care scenarios. Furthermore, increasing complexity in cancer clinical trial design has led to challenges such as protocol deviations, slow enrollment leading to lengthened durations of trial, and escalating costs. By contrast, pragmatic trials aim to assess intervention effectiveness in more representative patient populations under routine clinical conditions. Here, we review the principles, methodologies, challenges, and advantages of incorporating pragmatic features (PFs) into cancer clinical trials. We illustrate the application of pragmatic trial designs in oncology and discuss the QUASAR collaborative, TAPUR study, and the ongoing PRAGMATICA-LUNG trial. Although not all oncology trials may be amenable to adopting fully pragmatic designs, integration of PFs when feasible will enhance trial generalizability and real-world applicability. Project Pragmatica and similar initiatives advocate for the integration of real-world practice with clinical trials, fostering a nuanced approach to oncology research that balances efficacy and effectiveness assessments, ultimately with a goal of improving patient outcomes. |
| تواريخ الأحداث: |
Date Created: 20240521 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: |
20240522 |
| DOI: |
10.1200/EDBK_100040 |
| PMID: |
38771997 |
| قاعدة البيانات: |
MEDLINE |
