دورية أكاديمية
Threat-dependent scaling of prelimbic dynamics to enhance fear representation.
| العنوان: | Threat-dependent scaling of prelimbic dynamics to enhance fear representation. |
|---|---|
| المؤلفون: | Casanova JP; Cerebral Codes and Circuits Connectivity team, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France., Pouget C; Cerebral Codes and Circuits Connectivity team, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France., Treiber N; Cerebral Codes and Circuits Connectivity team, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France., Agarwal I; Cerebral Codes and Circuits Connectivity team, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France., Brimble MA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vetere G; Cerebral Codes and Circuits Connectivity team, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 10 rue Vauquelin, 75005 Paris, France. Electronic address: gisella.vetere@espci.fr. |
| المصدر: | Neuron [Neuron] 2024 Jul 17; Vol. 112 (14), pp. 2304-2314.e6. Date of Electronic Publication: 2024 May 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Fear*/physiology, Animals ; Male ; Prefrontal Cortex/physiology ; Neurons/physiology ; Rats ; Conditioning, Classical/physiology ; Freezing Reaction, Cataleptic/physiology |
| مستخلص: | Promptly identifying threatening stimuli is crucial for survival. Freezing is a natural behavior displayed by rodents toward potential or actual threats. Although it is known that the prelimbic cortex (PL) is involved in both risk evaluation and in fear and anxiety-like behavior expression, here we explored whether PL neuronal activity can dynamically represent different internal states of the same behavioral output (i.e., freezing). We found that freezing can always be decoded from PL activity at a population level. However, the sudden presentation of a fearful stimulus quickly reshaped the PL to a new neuronal activity state, an effect not observed in other cortical or subcortical regions examined. This shift changed PL freezing representation and is necessary for fear memory expression. Our data reveal the unique role of the PL in detecting threats and internally adjusting to distinguish between different freezing-related states in both unconditioned and conditioned fear representations. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: FLiCRE; fear; memory; miniscope; neuronal network; prelimbic cortex; shock |
| تواريخ الأحداث: | Date Created: 20240521 Date Completed: 20240718 Latest Revision: 20240719 |
| رمز التحديث: | 20240720 |
| DOI: | 10.1016/j.neuron.2024.04.029 |
| PMID: | 38772375 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
|---|---|
| DOI: | 10.1016/j.neuron.2024.04.029 |