دورية أكاديمية

Comprehensive quality evaluation of Lysimachia christinae Hance via fingerprint, spectrum-effect relationship, and quantitative analyses of multiple components by single marker.

التفاصيل البيبلوغرافية
العنوان: Comprehensive quality evaluation of Lysimachia christinae Hance via fingerprint, spectrum-effect relationship, and quantitative analyses of multiple components by single marker.
المؤلفون: LuoRong Q; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People's Republic of China., Tan LH; College of Pharmacy & College of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, People's Republic of China., Yu B; College of Traditional Chinese Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, People's Republic of China., Wu Y; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People's Republic of China., Luo J; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People's Republic of China., Cao WG; College of Traditional Chinese Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, People's Republic of China., Li J; College of Traditional Chinese Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, People's Republic of China., Chen H; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People's Republic of China.; College of Traditional Chinese Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, People's Republic of China., Zhang D; College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People's Republic of China.; College of Traditional Chinese Medicine, Chongqing College of Traditional Chinese Medicine, Chongqing, People's Republic of China.
المصدر: Phytochemical analysis : PCA [Phytochem Anal] 2024 May 21. Date of Electronic Publication: 2024 May 21.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 9200492 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1565 (Electronic) Linking ISSN: 09580344 NLM ISO Abbreviation: Phytochem Anal Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chichester, Sussex, UK : Wiley, c1990-
مستخلص: Background: Lysimachia christinae Hance (LCH) is a traditional medicine used to treat gallstone disease and cholecystitis. Despite its known anti-inflammatory and choleretic effects, its quality has not been extensively evaluated.
Objective: In this study, we aimed to establish a reliable quality evaluation method for LCH via fingerprint, spectrum-effect relationship, and quantitative analyses of multicomponents by a single marker (QAMS).
Methods: First, the fingerprints and anti-inflammatory and choleretic activities of 14 LCH batches were determined. Then, the gray relation analysis method was used to analyze the peak areas of the fingerprint profile and pharmacodynamic data. Subsequently, the characteristic peaks were tentatively identified using high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Finally, rutin was selected as the internal reference material, and QAMS was used to analyze the LCH components.
Results: Pharmacodynamic experiments confirmed that LCH exerted anti-inflammatory and choleretic effects. Moreover, 15 flavonoids related to the anti-inflammatory and choleretic effects of LCH were identified. Notably, relative error percentage between the QAMS and external standard method was less than 5%.
Conclusion: This study successfully established a comprehensive evaluation method for the qualitative and quantitative analyses of LCH.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: cstc2020jscx-dxwtBX0054 Chongqing Science and Technology Bureau; CSTB2022NSCQ-MSX1646 Chongqing Science and Technology Bureau; KJQN202215118 Chongqing Graduate Student Research Innovation Project; KJZD-M202215102 Chongqing Graduate Student Research Innovation Project; 2023-23-14 Chongqing QiHuang scholars support project
فهرسة مساهمة: Keywords: Lysimachia christinae Hance; anti‐inflammatory; choleretic; fingerprint techniques; quality evaluation
تواريخ الأحداث: Date Created: 20240521 Latest Revision: 20240521
رمز التحديث: 20240522
DOI: 10.1002/pca.3394
PMID: 38772567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-1565
DOI:10.1002/pca.3394