دورية أكاديمية
أعرض في EDS

Intracranial pressure following surgery of an unruptured intracranial aneurysm-a model for normal intracranial pressure in humans.

التفاصيل البيبلوغرافية
العنوان: Intracranial pressure following surgery of an unruptured intracranial aneurysm-a model for normal intracranial pressure in humans.
المؤلفون: Norager NH; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark. nicolas.norager@gmail.com., Lilja-Cyron A; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark., Riedel CS; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark., Holst AV; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark., Pedersen SH; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark., Juhler M; Clinic of Neurosurgery, Copenhagen University Hospital, Inge Lehmanns Vej 6, 2100, Copenhagen East, Denmark.; Clinic of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
المصدر: Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 May 21; Vol. 21 (1), pp. 44. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101553157 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-8118 (Electronic) Linking ISSN: 20458118 NLM ISO Abbreviation: Fluids Barriers CNS Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Biomed Central
مواضيع طبية MeSH: Intracranial Aneurysm*/surgery , Intracranial Aneurysm*/physiopathology , Intracranial Pressure*/physiology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Neurosurgical Procedures ; Posture/physiology ; Pulse Wave Analysis ; Prospective Studies
مستخلص: Objective: Optimizing the treatment of several neurosurgical and neurological disorders relies on knowledge of the intracranial pressure (ICP). However, exploration of normal ICP and intracranial pressure pulse wave amplitude (PWA) values in healthy individuals poses ethical challenges, and thus the current documentation remains scarce. This study explores ICP and PWA values for healthy adults without intracranial pathology expected to influence ICP.
Methods: Adult patients (age > 18 years) undergoing surgery for an unruptured intracranial aneurysm without any other neurological co-morbidities were included. Patients had a telemetric ICP sensor inserted, and ICP was measured in four different positions: supine, lateral recumbent, standing upright, and 45-degree sitting, at day 1, 14, 30, and 90 following the surgery.
Results: ICP in each position did not change with time after surgery. Median ICP was 6.7 mmHg and median PWA 2.1 mmHg in the supine position, while in the upright standing position median ICP was - 3.4 mmHg and median PWA was 1.9 mmHg. After standardization of the measurements from the transducer site to the external acoustic meatus, the median ICP midbrain was 8.3 mmHg in the supine position and 1.2 mmHg in the upright standing position.
Conclusion: Our study provides insights into normal ICP dynamics in healthy adults following a uncomplicated surgery for an unruptured aneurysm. These results suggest a slightly wider normal reference range for invasive intracranial pressure than previously suggested, and present the first normal values for PWA in different positions. Further studies are, however, essential to enhance our understanding of normal ICP. Trial registration The study was preregistered at www.
Clinicaltrials: gov (NCT03594136) (11 July 2018).
(© 2024. The Author(s).)
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معلومات مُعتمدة: NNF17OC0024718 Novo Nordisk Fonden
فهرسة مساهمة: Keywords: Intracranial pressure (ICP); Normal ICP reference value; Telemetric ICP monitoring; Unruptured intracranial aneurysm
سلسلة جزيئية: ClinicalTrials.gov NCT03594136
تواريخ الأحداث: Date Created: 20240522 Date Completed: 20240522 Latest Revision: 20240524
رمز التحديث: 20240524
مُعرف محوري في PubMed: PMC11110356
DOI: 10.1186/s12987-024-00549-1
PMID: 38773608
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-8118
DOI:10.1186/s12987-024-00549-1