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Increased Vasoactive Intestinal Peptide (VIP) in polycystic ovary syndrome patients undergoing IVF.

التفاصيل البيبلوغرافية
العنوان: Increased Vasoactive Intestinal Peptide (VIP) in polycystic ovary syndrome patients undergoing IVF.
المؤلفون: Sallicandro L; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.; Department of Medicine and Surgery, Perugia Medical School, University of Perugia, Perugia, Italy., Gliozheni E; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.; Department of Medicine and Surgery, Perugia Medical School, University of Perugia, Perugia, Italy., Feudi D; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy., Sabbatini P; Department of Medicine and Surgery, Perugia Medical School, University of Perugia, Perugia, Italy., Pellegrino RM; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy., Alabed HBR; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy., Baldini D; In Vitro Fertilization (IVF) Center, Momo Fertilife, Bisceglie, Italy., Gerli S; Department of Medicine and Surgery, Perugia Medical School, University of Perugia, Perugia, Italy.; Department of Obstetrics and Gynecology, Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy., Alviggi C; Department of Clinical Gynecological Emergency, Obstetrics and Reproductive Medicine, University Federico II, Naples, Italy., Cascardi E; Department of Medical Sciences, University of Turin, Turin, Italy., Cicinelli E; Department of Interdisciplinary Medicine (DIM), University of Bari 'Aldo Moro', Bari, Italy., Malvasi A; Department of Interdisciplinary Medicine (DIM), University of Bari 'Aldo Moro', Bari, Italy., Fioretti B; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.; Department of Obstetrics and Gynecology, Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 May 07; Vol. 15, pp. 1331282. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/blood , Vasoactive Intestinal Peptide*/metabolism , Vasoactive Intestinal Peptide*/blood , Fertilization in Vitro* , Follicular Fluid*/metabolism, Humans ; Female ; Adult ; Estradiol/blood ; Estradiol/metabolism ; Anti-Mullerian Hormone/blood ; Anti-Mullerian Hormone/metabolism ; Case-Control Studies
مستخلص: Introduction: Polycystic ovary syndrome (PCOS) is a common multifactorial and polygenic disorder of the endocrine system, affecting up to 20% of women in reproductive age with a still unknown etiology. Follicular fluid (FF) represents an environment for the normal development of follicles rich in metabolites, hormones and neurotransmitters, but in some instances of PCOS the composition can be different. Vasoactive intestinal peptide (VIP) is an endogenous autonomic neuropeptide involved in follicular atresia, granulosa cell physiology and steroidogenesis.
Methods: ELISA assays were performed to measure VIP and estradiol levels in human follicular fluids, while AMH, FSH, LH, estradiol and progesterone in the plasma were quantified by chemiluminescence. UHPLC/QTOF was used to perform the untargeted metabolomic analysis.
Results: Our ELISA and metabolomic results show: i) an increased concentration of VIP in follicular fluid of PCOS patients (n=9) of about 30% with respect to control group (n=10) (132 ± 28 pg/ml versus 103 ± 26 pg/ml, p=0,03) in women undergoing in vitro fertilization (IVF), ii) a linear positive correlation (p=0.05, r=0.45) between VIP concentration and serum Anti-Müllerian Hormone (AMH) concentration and iii) a linear negative correlation between VIP and noradrenaline metabolism. No correlation between VIP and estradiol (E2) concentration in follicular fluid was found. A negative correlation was found between VIP and noradrenaline metabolite 3,4-dihydroxyphenylglycolaldehyde (DOPGAL) in follicular fluids.
Conclusion: VIP concentration in follicular fluids was increased in PCOS patients and a correlation was found with noradrenaline metabolism indicating a possible dysregulation of the sympathetic reflex in the ovarian follicles. The functional role of VIP as noradrenergic modulator in ovarian physiology and PCOS pathophysiology was discussed.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Sallicandro, Gliozheni, Feudi, Sabbatini, Pellegrino, Alabed, Baldini, Gerli, Alviggi, Cascardi, Cicinelli, Malvasi and Fioretti.)
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فهرسة مساهمة: Keywords: In Vitro Fertilization (IVF); PCOS (polycystic ovarian syndrome); VIP (vasoactive intestinal peptide); follicular fluid; metabolomic; noradrenalin (NA); ovarian innervation
تواريخ الأحداث: Date Created: 20240522 Date Completed: 20240522 Latest Revision: 20240523
رمز التحديث: 20240523
مُعرف محوري في PubMed: PMC11106456
DOI: 10.3389/fendo.2024.1331282
PMID: 38774232
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2024.1331282