دورية أكاديمية
Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes.
| العنوان: | Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes. |
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| المؤلفون: | Bhave VM; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Oladele CR; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Ament Z; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Kijpaisalratana N; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Jones AC; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Couch CA; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Patki A; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Garcia Guarniz AL; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Bennett A; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Crowe M; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Irvin MR; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham., Kimberly WT; From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham. |
| المصدر: | Neurology [Neurology] 2024 Jun 11; Vol. 102 (11), pp. e209432. Date of Electronic Publication: 2024 May 22. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Minneapolis. |
| مواضيع طبية MeSH: | Stroke*/epidemiology , Stroke*/prevention & control , Fast Foods*/adverse effects, Humans ; Female ; Male ; Middle Aged ; Aged ; Prospective Studies ; White People ; United States/epidemiology ; Diet, Mediterranean ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cohort Studies ; Dietary Approaches To Stop Hypertension ; Incidence ; Risk Factors ; Adult ; Food Handling ; Food, Processed |
| مستخلص: | Background and Objectives: Ultra-processed foods (UPFs) are linked to cardiometabolic diseases and neurologic outcomes, such as cognitive decline and stroke. However, it is unclear whether food processing confers neurologic risk independent of dietary pattern information. We aimed to (1) investigate associations between UPFs and incident cognitive impairment and stroke and (2) compare these associations with other commonly recommended dietary patterns in the REasons for Geographic and Racial Differences in Stroke study. This prospective, observational cohort study enrolled Black and White adults in the United States from 2003 to 2007. Methods: The NOVA system was used to categorize items from a baseline food frequency questionnaire according to the level of processing. Participants with incomplete or implausible self-reported dietary data were excluded. Consumption for each category (grams) was normalized to total grams consumed. Scores quantifying adherence to a Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet were also calculated. Incident cognitive impairment was defined using performance relative to a normative sample on memory and fluency assessments. Incident stroke was identified through adjudicated review of medical records. Results: The cognitive impairment cohort (n = 14,175) included participants without evidence of impairment at baseline who underwent follow-up testing. The stroke cohort (n = 20,243) included participants without a history of stroke. In multivariable Cox proportional hazards models, a 10% increase in relative intake of UPFs was associated with higher risk of cognitive impairment (hazard ratio [HR] = 1.16, 95% CI 1.09-1.24, p = 1.01 × 10 -5 ) and intake of unprocessed or minimally processed foods with lower risk of cognitive impairment (HR = 0.88, 95% CI 0.83-0.94, p = 1.83 × 10 -4 ). Greater intake of UPFs (HR = 1.08, 95% CI 1.02-1.14, p = 1.12 × 10 -2 ) and unprocessed or minimally processed foods (HR = 0.91, 95% CI 0.86-0.95, p = 2.13 × 10 -4 ) were also associated with risk of stroke in multivariable Cox models. The effect of UPFs on stroke risk was greater among Black than White participants (UPF-by-race interaction HR = 1.15, 95% CI 1.03-1.29, p = 1.50 × 10 -2 ). Associations between UPFs and both cognitive impairment and stroke were independent of adherence to the Mediterranean, DASH, and MIND diets. Discussion: Food processing may be important to brain health in older adults independent of known risk factors and adherence to recommended dietary patterns. |
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| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240522 Latest Revision: 20240615 |
| رمز التحديث: | 20240615 |
| مُعرف محوري في PubMed: | PMC11175629 |
| DOI: | 10.1212/WNL.0000000000209432 |
| PMID: | 38776524 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-632X |
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| DOI: | 10.1212/WNL.0000000000209432 |