دورية أكاديمية
Design and synthesis of S-citalopram-imprinted polymeric sorbent: Characterization and application in enantioselective separation.
| العنوان: | Design and synthesis of S-citalopram-imprinted polymeric sorbent: Characterization and application in enantioselective separation. |
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| المؤلفون: | Alharbi HY; Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia. Electronic address: hharbi@taibahu.edu.sa., Alnoman RB; Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., Aljohani MS; Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia., Monier M; Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. Electronic address: monierchem@yahoo.com., Tawfik EH; Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. |
| المصدر: | Journal of chromatography. A [J Chromatogr A] 2024 Jul 19; Vol. 1727, pp. 464925. Date of Electronic Publication: 2024 Apr 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| مواضيع طبية MeSH: | Citalopram*/chemistry , Citalopram*/isolation & purification , Citalopram*/chemical synthesis , Molecular Imprinting*, Stereoisomerism ; Adsorption ; Polymers/chemistry ; Polymers/chemical synthesis ; Chromatography, High Pressure Liquid/methods |
| مستخلص: | The current work describes the efficient creation and employment of a new S-citalopram selective polymeric sorbent, made from poly(divinylbenzene-maleic anhydride-styrene). The process began by using suspension polymerization technique in the synthesis of poly(styrene-maleic anhydride-divinylbenzene) microparticles. These were then modified with ethylenediamine, developing an amido-succinic acid-based polymer derivative. The S-citalopram, a cationic molecule, was loaded onto these developed anionic polymer particles. Subsequently, the particles were post-crosslinked using glyoxal, which reacts with the amino group residues of ethylenediamine. S-citalopram was extracted from this matrix using an acidic solution, which also left behind stereo-selective cavities in the S-citalopram imprinted polymer, allowing for the selective re-adsorption of S-citalopram. The attributes of the polymer were examined through methods such as 13 C NMR, FTIR, thermogravemetric and elemental analyses. SEM was used to observe the shapes and structures of the particles. The imprinted polymers demonstrated a significant ability to adsorb S-citalopram, achieving a capacity of 878 mmol/g at a preferred pH level of 8. It proved efficient in separating enantiomers of (±)-citalopram via column methods, achieving an enantiomeric purity of 97 % for R-citalopram upon introduction and 92 % for S-citalopram upon release. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chiral separation; Citalopram; Maleic anhydride; Molecular-imprinting |
| المشرفين على المادة: | 0DHU5B8D6V (Citalopram) 0 (Polymers) |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240530 Latest Revision: 20240530 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1016/j.chroma.2024.464925 |
| PMID: | 38776603 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3778 |
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| DOI: | 10.1016/j.chroma.2024.464925 |