دورية أكاديمية
Office-based respiratory assessment in patients with generalized myasthenia gravis.
| العنوان: | Office-based respiratory assessment in patients with generalized myasthenia gravis. |
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| المؤلفون: | Alcantara M; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Barnett-Tapia C; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Bril V; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Mannan S; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Shabanpour J; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Riaz S; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Ng E; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada., Ryan C; Department of Medicine, Division of Respirology, University of Toronto, Toronto, Ontario, Canada., Katzberg H; Department of Medicine, Division of Neurology, Prosserman Family Neuromuscular clinic, University of Toronto, Toronto, Ontario, Canada. Electronic address: hans.katzberg@utoronto.ca. |
| المصدر: | Neuromuscular disorders : NMD [Neuromuscul Disord] 2024 Jul; Vol. 40, pp. 1-6. Date of Electronic Publication: 2024 May 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 9111470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2364 (Electronic) Linking ISSN: 09608966 NLM ISO Abbreviation: Neuromuscul Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Myasthenia Gravis*/physiopathology , Myasthenia Gravis*/diagnosis , Quality of Life* , Respiratory Function Tests*, Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Vital Capacity ; Surveys and Questionnaires |
| مستخلص: | Patients with myasthenia gravis (MG) can present with respiratory dysfunction, ranging from exercise intolerance to overt respiratory failure, increased fatigue, or sleep-disordered breathing. To investigate the value of multiple respiratory tests in MG, we performed clinical and respiratory assessments in patients with mild to moderate generalized disease. One-hundred and thirty-six patients completed the myasthenia gravis quality-of-life score(MG-QOL-15), myasthenia gravis impairment index(MGII), Epworth sleepiness scale(ESS), University of California-San Diego Shortness of Breath Questionnaire(UCSD-SOB), Modified Medical Research Council Dyspnea Scales(MRC-DS), supine and upright forced vital capacity(FVC), maximal inspiratory pressures(MIPs) and sniff nasal inspiratory pressures(SNIP). Seventy-three (54 %) had respiratory and/or bulbar symptoms and 45 (33 %) had baseline abnormal FVC, with no significant postural changes (p = 0.89); 55 (40.4 %) had abnormal MIPs and 50 (37 %) had abnormal SNIPs. Overall, there were low scores on respiratory and disability scales. Females had increased odds of presenting with abnormal FVC (OR 2.89, p = 0.01) and MIPs (OR 2.48, p = 0.022). There were significant correlations between MIPs, FVC and SNIPs; between MGII/MG-QOL15 and UCSD-SOB/MRC-DS and between ESS and respiratory scales in the whole group. Our data suggests that office-based respiratory measurements are a useful screening method for stable MG patients, even when presenting with minimal respiratory symptoms and no significant disability. Competing Interests: Declaration of competing interest On behalf of all authors, I confirm that there are no conflict or competing interests related to this work. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Forced vital capacity; Maximal inspiratory pressure; Myasthenia gravis; Quality of life; Respiratory dysfunction |
| تواريخ الأحداث: | Date Created: 20240522 Date Completed: 20240612 Latest Revision: 20240612 |
| رمز التحديث: | 20240613 |
| DOI: | 10.1016/j.nmd.2024.05.005 |
| PMID: | 38776756 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2364 |
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| DOI: | 10.1016/j.nmd.2024.05.005 |