دورية أكاديمية
The Potential of Cannabichromene (CBC) as a Therapeutic Agent .
| العنوان: | The Potential of Cannabichromene (CBC) as a Therapeutic Agent . |
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| المؤلفون: | Sepulveda DE; Pharmacology, Penn State College of Medicine, United States., Vrana KE; Dept. of Pharmacology, Penn State College of Medicine, United States., Kellogg JJ; Penn State University, United States., Bisanz JE; Penn State University, United States., Desai D; Penn State College of Medicine, United States., Graziane NM; Penn State Milton S. Hershey Medical Center, United States., Raup-Konsavage WM; Pharmacology, Penn State College of Medicine, United States wkonsavage@pennstatehealth.psu.edu. |
| المصدر: | The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 May 22. Date of Electronic Publication: 2024 May 22. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics Original Publication: Baltimore : Williams & Wilkins |
| مستخلص: | There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa The two most abundant cannabinoids (Δ 9 -tetrahydrocannabinol and cannabidiol) have been governmentally approved to treat selected medical conditions; however, the plant produces over 100 cannabinoids, including cannabichromene (CBC). While the cannabinoids share a common precursor molecule, cannabigerol, they are structurally and pharmacologically unique. These differences may engender differing therapeutic potentials. In this review, we will examine what is currently known about CBC with regards to pharmacodynamics, pharmacokinetics, and receptor profile. We will also discuss the therapeutic areas that have been examined for this cannabinoid, notably antinociceptive, antibacterial, and anti-seizure activities. Finally, we will discuss areas where new research is needed and potential novel medicinal applications for CBC. Significance Statement Cannabichromene (CBC) has been suggested to have disparate therapeutic benefits such as anti-inflammatory, anticonvulsant, antibacterial, and antinociceptive effects. Most of the focus on the medical benefits of cannabinoids has been focused on THC and CBD. The preliminary studies on CBC indicate that this phytocannabinoid may have unique therapeutic potential that warrants further investigation. Following easier access to hemp, CBC products are commercially available over-the-counter and are being widely utilized with little or no evidence of their safety or efficacy. (© 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.) |
| فهرسة مساهمة: | Keywords: cannabinoid receptors; cannabinoids; transient receptor potential (TRP) receptors |
| تواريخ الأحداث: | Date Created: 20240522 Latest Revision: 20240522 |
| رمز التحديث: | 20240523 |
| DOI: | 10.1124/jpet.124.002166 |
| PMID: | 38777605 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1521-0103 |
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| DOI: | 10.1124/jpet.124.002166 |