دورية أكاديمية
Liver function and portal-systemic shunting quantified by the oral cholate challenge test and risk for large oesophageal varices.
| العنوان: | Liver function and portal-systemic shunting quantified by the oral cholate challenge test and risk for large oesophageal varices. |
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| المؤلفون: | Hassanein T; Southern California Research Center, Coronado, California, USA., Keaveny AP; Mayo Clinic, Jacksonville, Florida, USA., Mantry P; The Liver Institute at Methodist Dallas Medical Center, Dallas, Texas, USA., Smith AD; Syneos Health, Morrisville, North Carolina, USA., McRae MP; Custom DX Solutions LLC, Houston, Texas, USA., Kittelson J; Consultant to HepQuant LLC, Denver, Colorado, USA., Helmke S; HepQuant LLC, Denver, Colorado, USA., Everson GT; HepQuant LLC, Denver, Colorado, USA. |
| مؤلفون مشاركون: | SHUNT‐V Investigators |
| المصدر: | Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2024 Jul; Vol. 60 (2), pp. 246-256. Date of Electronic Publication: 2024 May 22. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2036 (Electronic) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987- |
| مواضيع طبية MeSH: | Esophageal and Gastric Varices*/physiopathology , Esophageal and Gastric Varices*/etiology , Esophageal and Gastric Varices*/diagnosis , Liver Function Tests*/methods , Severity of Illness Index*, Humans ; Male ; Female ; Middle Aged ; Adult ; Prospective Studies ; Aged ; Endoscopy, Digestive System/methods ; Risk Factors ; Liver/physiopathology ; Liver/blood supply |
| مستخلص: | Background: The quantitative HepQuant SHUNT test of liver function and physiology generates a disease severity index (DSI) that correlates with risk for clinical complications, such as large oesophageal varices (LEVs). A derivative test, HepQuant DuO, generates an equivalent DSI and simplifies testing by requiring only oral administration of the test solution and two blood samples at 20 and 60 min. Aims: Since the DSIs measured from DuO and SHUNT are equivalent, we compared the diagnostic performance for large oesophageal varices (LEVs) between the DSIs measured from DuO and SHUNT tests. Methods: This study combined the data from two prospectively conducted US studies: HALT-C and SHUNT-V. A total of 455 subjects underwent both the SHUNT test and esophagogastroduodenoscopy (EGD). Results: DSI scores correlated with the probability of LEVs (p < 0.001) and demonstrated a stepwise increase from healthy lean controls without liver disease to subjects with chronic liver disease and no, small or large varices. Furthermore, a cutoff of DSI ≤ 18.3 from DuO had a sensitivity of 0.98 (missing only one case) and, if applied to the endoscopy (EGD) decision, would have prevented 188 EGDs (41.3%). The AUROC for DSI from DuO did not differ from that of the reference SHUNT test method (0.82 versus 0.81, p = 0.3500). Conclusions: DSI from HepQuant DuO links liver function and physiology to the risk of LEVs across a wide spectrum of patient characteristics, disease aetiologies and liver disease severity. DuO is minimally invasive, easy to administer, quantitative and may aid the decision to avoid or perform EGD for LEVs. (© 2024 John Wiley & Sons Ltd.) |
| التعليقات: | Comment in: Aliment Pharmacol Ther. 2024 Aug;60(3):403-404. doi: 10.1111/apt.18113. (PMID: 38924130) |
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| معلومات مُعتمدة: | M01RR-00051 United States DK NIDDK NIH HHS; National Institute of Allergy and Infectious Diseases; National Center on Minority Health and Health Disparities; M01 RR000065 United States RR NCRR NIH HHS; M01RR-00827 United States DK NIDDK NIH HHS; NIH General Clinical Research Centers; M01RR-00065 United States DK NIDDK NIH HHS; Hoffmann-La Roche, Inc.; M01 RR000827 United States RR NCRR NIH HHS; M01 RR000051 United States RR NCRR NIH HHS; United States CA NCI NIH HHS |
| فهرسة مساهمة: | Investigator: K Bambha; M Fuchs; RK Gilroy; KR Reddy; ML Shiffman; RS Rahimi; PA Hellstern; JM Hill; Z Kayali; D Denham; K Qureshi; B Smith; KJ Lucas; MD Leise; S Glover; TD Amankonah; B Patel; G Reiss; FB Newman; VK Bhagat; WK Syn; E Mena; A Kohli; N Ravendhran; J Strobel |
| تواريخ الأحداث: | Date Created: 20240523 Date Completed: 20240627 Latest Revision: 20240828 |
| رمز التحديث: | 20240828 |
| مُعرف محوري في PubMed: | PMC11348877 |
| DOI: | 10.1111/apt.18054 |
| PMID: | 38778481 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2036 |
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| DOI: | 10.1111/apt.18054 |