دورية أكاديمية
أعرض في EDS

Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial.

التفاصيل البيبلوغرافية
العنوان: Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial.
المؤلفون: Ubben JFH; Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Heuts S; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Cardiothoracic Surgery, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Delnoij TSR; Department of Intensive Care Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.; Department of Cardiology, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Suverein MM; Department of Intensive Care Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Hermanides RC; Department of Cardiology, Isala Clinics, Zwolle, the Netherlands., Otterspoor LC; Department of Intensive Care Medicine, Catharina Hospital, Eindhoven, the Netherlands., Kraemer CVE; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands., Vlaar APJ; Department of Intensive Care Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands., van der Heijden JJ; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Scholten E; Department of Intensive Care Medicine, Sint Antonius Hospital, Nieuwegein, the Netherlands., den Uil C; Department of Intensive Care Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Intensive Care Medicine, Maasstad Ziekenhuis, Rotterdam, the Netherlands.; Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands., Dos Reis Miranda D; Department of Intensive Care Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Akin S; Department of Intensive Care Medicine, Haga Ziekehuis, The Hague, the Netherlands., de Metz J; Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands., van der Horst ICC; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Intensive Care Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Winkens B; Department of Methodology and Statistics, Maastricht University, Maastricht, the Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands., Maessen JG; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Cardiothoracic Surgery, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., Lorusso R; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Department of Cardiothoracic Surgery, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands., van de Poll MCG; Department of Intensive Care Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.; School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.; Department of Surgery, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.
المصدر: Resuscitation plus [Resusc Plus] 2024 May 13; Vol. 18, pp. 100657. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101774410 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-5204 (Electronic) Linking ISSN: 26665204 NLM ISO Abbreviation: Resusc Plus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2020]-
مستخلص: Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used as a supportive treatment for refractory out-of-hospital cardiac arrest (OHCA). Still, there is a paucity of data evaluating favorable and unfavorable prognostic characteristics in patients considered for ECPR.
Methods: We performed a previously unplanned post-hoc analysis of the multicenter randomized controlled INCEPTION-trial. The study group consisted of patients receiving ECPR, irrespective of initial group randomization. The patients were divided into favorable survivors (cerebral performance category [CPC] 1-2) and unfavorable or non-survivors (CPC 3-5).
Results: In the initial INCEPTION-trial, 134 patients were randomized. ECPR treatment was started in 46 (66%) of 70 patients in the ECPR treatment arm and 3 (4%) of 74 patients in the conventional treatment arm. No statistically significant differences in baseline characteristics, medical history, or causes of arrest were observed between survivors ( n  = 5) and non-survivors ( n  = 44). More patients in the surviving group had a shockable rhythm at the time of cannulation (60% vs. 14%, p  = 0.037), underwent more defibrillation attempts (13 vs. 6, p  = 0.002), and received higher dosages of amiodarone (450 mg vs 375 mg, p  = 0.047) despite similar durations of resuscitation maneuvers. Furthermore, non-survivors more frequently had post-ECPR implantation adverse events.
Conclusion: The persistence of ventricular arrhythmia is a favorable prognostic factor in patients with refractory OHCA undergoing an ECPR-based treatment. Future studies are warranted to confirm this finding and to establish additional prognostic factors. Clinical trial Registration: clinicaltrials.gov registration number NCT03101787.
Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ‘Roberto Lorusso reports consulting fees from Medtronic, LivaNova, Getinge, and Abiomed and participates in an advisory board of Eurosets and Xenios, which are not related to this work. All other authors report no conflicts of interest.’.
(© 2024 The Author(s).)
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فهرسة مساهمة: Keywords: ECPR; OHCA; Prognostic factors; Refractory Arrest; Resuscitation; Ventricular Arrhytmias
سلسلة جزيئية: ClinicalTrials.gov NCT03101787
تواريخ الأحداث: Date Created: 20240523 Latest Revision: 20240524
رمز التحديث: 20240524
مُعرف محوري في PubMed: PMC11108965
DOI: 10.1016/j.resplu.2024.100657
PMID: 38778803
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-5204
DOI:10.1016/j.resplu.2024.100657