دورية أكاديمية
2023 Society for Academic Emergency Medicine Consensus Conference on Precision Emergency Medicine: Development of a policy-relevant, patient-centered research agenda.
العنوان: | 2023 Society for Academic Emergency Medicine Consensus Conference on Precision Emergency Medicine: Development of a policy-relevant, patient-centered research agenda. |
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المؤلفون: | Strehlow M; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Gisondi MA; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Caretta-Weyer H; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Ankel F; Department of Emergency Medicine, Regions Hospital, St. Paul, Minnesota, USA., Brackett A; Harvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, Connecticut, USA., Brar P; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Chan TM; School of Medicine, Toronto Metropolitan University, Toronto, Ontario, Canada.; Department of Medicine, Division of Emergency Medicine, McMaster University, Toronto, Ontario, Canada., Garabedian A; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Gunn B; Health Sciences Library, Baystate Health, Springfield, Massachusetts, USA., Isaacs E; Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA., von Isenburg M; School of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Jarman A; Department of Emergency Medicine, University of California, Davis, Sacramento, California, USA., Kuehl D; Department of Emergency Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Limkakeng AT; School of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Lydston M; Treadwell Library, Massachusetts General Hospital, Boston, Massachusetts, USA., McGregor A; Prisma Health, University of South Carolina School of Medicine, Greenville, South Carolina, USA., Pierce A; Department of Emergency Medicine, UT Southwestern Medical Center, Dallas, Texas, USA., Raven MC; Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA., Salhi RA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Stave C; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Tan J; Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA., Taylor RA; Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Wong HN; Lane Medical Library, Stanford University, Stanford, California, USA., Yiadom MYAB; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA., Zachrison KS; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Vogel J; Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA. |
المصدر: | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine [Acad Emerg Med] 2024 May 23. Date of Electronic Publication: 2024 May 23. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 9418450 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1553-2712 (Electronic) Linking ISSN: 10696563 NLM ISO Abbreviation: Acad Emerg Med Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Hoboken, N.J. : Wiley Original Publication: Philadelphia, PA : Hanley & Belfus, c1993- |
مستخلص: | Objectives: Precision medicine is data-driven health care tailored to individual patients based on their unique attributes, including biologic profiles, disease expressions, local environments, and socioeconomic conditions. Emergency medicine (EM) has been peripheral to the precision medicine discourse, lacking both a unified definition of precision medicine and a clear research agenda. We convened a national consensus conference to build a shared mental model and develop a research agenda for precision EM. Methods: We held a conference to (1) define precision EM, (2) develop an evidence-based research agenda, and (3) identify educational gaps for current and future EM clinicians. Nine preconference workgroups (biomedical ethics, data science, health professions education, health care delivery and access, informatics, omics, population health, sex and gender, and technology and digital tools), comprising 84 individuals, garnered expert opinion, reviewed relevant literature, engaged with patients, and developed key research questions. During the conference, each workgroup shared how they defined precision EM within their domain, presented relevant conceptual frameworks, and engaged a broad set of stakeholders to refine precision EM research questions using a multistage consensus-building process. Results: A total of 217 individuals participated in this initiative, of whom 115 were conference-day attendees. Consensus-building activities yielded a definition of precision EM and key research questions that comprised a new 10-year precision EM research agenda. The consensus process revealed three themes: (1) preeminence of data, (2) interconnectedness of research questions across domains, and (3) promises and pitfalls of advances in health technology and data science/artificial intelligence. The Health Professions Education Workgroup identified educational gaps in precision EM and discussed a training roadmap for the specialty. Conclusions: A research agenda for precision EM, developed with extensive stakeholder input, recognizes the potential and challenges of precision EM. Comprehensive clinician training in this field is essential to advance EM in this domain. (© 2024 The Author(s). Academic Emergency Medicine published by Wiley Periodicals LLC on behalf of Society for Academic Emergency Medicine.) |
References: | Wilson B, Nicholls SG. The Human Genome Project, and recent advances in personalized genomics. RMHP. 2015;8:9‐20. National Research Council (US) Committee on A Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease. National Academies Press (US); 2011 http://www.ncbi.nlm.nih.gov/books/NBK91503/. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372(9):793‐795. Dzau VJ, Ginsburg GS. Realizing the full potential of precision medicine in health and health care. JAMA. 2016;316(16):1659‐1660. Feero WG, Wicklund CA, Veenstra D. Precision medicine, genome sequencing, and improved population health. JAMA. 2018;319(19):1979‐1980. Kass‐Hout TA, Stevens LM, Hall JL. American Heart Association precision medicine platform. Circulation. 2018;137(7):647‐649. Gilard V, Derrey S, Marret S, Bekri S, Tebani A. Precision neurosurgery: a path forward. JPM. 2021;11(10):1019. Introduction—precision surgery. Eur J Surg Oncol. 2017;43(5):iii. Minor L. Discovering Precision Health: Predict, Prevent and Cure to Advance Health and Wellbeing. 1st ed. Wiley‐Blackwell; 2020. Kikano S. Precision medicine in pediatric cardiology. Pediatr Ann. 2022;51(10):e390‐e395. Weldy CS, Ashley EA. Towards precision medicine in heart failure. Nat Rev Cardiol. 2021;18(11):745‐762. Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R. Review of precision cancer medicine: evolution of the treatment paradigm. Cancer Treat Rev. 2020;86:102019. Mateo J, Steuten L, Aftimos P, et al. Delivering precision oncology to patients with cancer. Nat Med. 2022;28(4):658‐665. Lee S‐H. Role of genetics in preventive cardiology: focused on dyslipidemia. Korean Circ J. 2021;51(11):899‐907. Ashina M, Terwindt GM, Al‐Karagholi MA‐M, et al. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021;397(10283):1496‐1504. Keshavan MS, Clementz BA. Precision medicine for psychosis: a revolution at the interface of psychiatry and neurology. Nat Rev Neurol. 2023;19(4):193‐194. https://www.nature.com/articles/s41582‐023‐00788‐0. Hampel H, Gao P, Cummings J, et al. The foundation and architecture of precision medicine in neurology and psychiatry. Trends Neurosci. 2023;46(3):176‐198. Williams LM, Hack LM. A precision medicine–based, ‘fast‐fail’ approach for psychiatry. Nat Med. 2020;26(5):653‐654. Limkakeng AT, Monte AA, Kabrhel C, et al. Systematic molecular phenotyping: a path toward precision emergency medicine? Acad Emerg Med. 2016;23(10):1097‐1106. Schultebraucks K, Shalev AY, Michopoulos V, et al. A validated predictive algorithm of post‐traumatic stress course following emergency department admission after a traumatic stressor. Nat Med. 2020;26(7):1084‐1088. Taylor RA, Pare JR, Venkatesh AK, et al. Prediction of in‐hospital mortality in emergency department patients with sepsis: a local big data–driven, machine learning approach. Acad Emerg Med. 2016;23(3):269‐278. Stopyra JP, Riley RF, Hiestand BC, et al. The HEART pathway randomized controlled trial one‐year outcomes. Acad Emerg Med. 2019;26(1):41‐50. Wolf SJ, McCubbin TR, Feldhaus KM, Faragher JP, Adcock DM. Prospective validation of wells criteria in the evaluation of patients with suspected pulmonary embolism. Ann Emerg Med. 2004;44(5):503‐510. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: a Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke [Internet]. 2019;50(12):e344‐e418. doi:10.1161/STR.0000000000000211. Ahmed L, Constantinidou A, Chatzittofis A. Patients’ perspectives related to ethical issues and risks in precision medicine: a systematic review. Front Med. 2023;10:1215663. Chan T, Thoma B, Finnell J, et al. Precision medicine within health professions education: defining a research agenda for emergency medicine using a foresight and strategy technique (FaST) review. AEM Educ Train. 2024;8:s5‐s16. 10.1002/aet2.10983. Jamison DT, Gelband H, Horton S, et al. Disease Control Priorities, Third Edition (Volume 9): Improving Health and Reducing Poverty. World Bank; 2017 http://hdl.handle.net/10986/28877. Tadesse Gebremedhin L, Nsanzimana S, Lamin Samateh A, et al. A call to invest in emergency, critical and operative care for universal health coverage. Nat Med. 2023;29(7):1591‐1592. Zink BJ. Anyone, Anything, Anytime: A History of Emergency Medicine. 2nd ed. American College of Emergency Physicians; 2018. Vigilante K, Escaravage S, McConnell M. Big data and the intelligence community—lessons for health care. N Engl J Med. 2019;380(20):1888‐1890. Davenport T, Kalakota R. The potential for artificial intelligence in healthcare. Future Healthc J. 2019;6(2):94‐98. Rose C, Barber R, Preiksaitis C, et al. A conference (missingness in action) to address missingness in data and AI in health care: qualitative thematic analysis. J Med Internet Res. 2023;25:e49314. |
معلومات مُعتمدة: | Society for Academic Emergency Medicine; School of Medicine, Stanford University; R13HS029275 Agency for Healthcare Research and Quality |
تواريخ الأحداث: | Date Created: 20240523 Latest Revision: 20240523 |
رمز التحديث: | 20240523 |
DOI: | 10.1111/acem.14932 |
PMID: | 38779704 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1553-2712 |
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DOI: | 10.1111/acem.14932 |