دورية أكاديمية
Investigating the role of axonal ion channel cooperativity in action potential dynamics: Studies on Hodgkin-Huxley's model.
| العنوان: | Investigating the role of axonal ion channel cooperativity in action potential dynamics: Studies on Hodgkin-Huxley's model. |
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| المؤلفون: | Kumar J; Department of Physics & Astrophysics, University of Delhi, Delhi 110007, India., Gupta PD; Department of Physics & Astrophysics, University of Delhi, Delhi 110007, India., Ghosh S; Department of Biophysics, University of Delhi South Campus, New Delhi 110021, India. Electronic address: subho@south.du.ac.in. |
| المصدر: | Biophysical chemistry [Biophys Chem] 2024 Aug; Vol. 311, pp. 107257. Date of Electronic Publication: 2024 May 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0403171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4200 (Electronic) Linking ISSN: 03014622 NLM ISO Abbreviation: Biophys Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science B.V Original Publication: Amsterdam, North-Holland Pub. Co. |
| مواضيع طبية MeSH: | Action Potentials* , Axons*/metabolism , Ion Channels*/metabolism , Ion Channels*/chemistry, Models, Neurological ; Ion Channel Gating ; Humans ; Animals |
| مستخلص: | Voltage-gated ion channels play an important role in generating action potential in neurons. These ion channels are found to be in localized cluster form on the axonal membrane surface and behave cooperatively. However, in Hodgkin & Huxley's model of action potential the ion channels are considered to function independently. According to some recent reports, the activity of an ion channel is influenced by the neighboring ion channels' activities. We have modified the Hodgkin-Huxley's model based on our previous studies on cooperativity among ion channels. Computational analysis of the proposed model shows that the initiation of the action potential, amplitude and hyperpolarization are affected significantly by the cooperative interactions among the voltage-gated ion channels present on the axonal membrane surface. These results are qualitatively supported by the existing experimental facts. Competing Interests: Declaration of competing interest This is to state that none of the authors of our paper (Jitender Kumar, Patrick Das Gupta & Subhendu Ghosh) has any conflict of interest (mutual or with any other scientists). This statement is related to the present submission of our manuscript “Investigating the role of axonal ion channel cooperativity in action potential dynamics: Studies on Hodgkin-Huxley's model” to your esteemed journal. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Action potential; Cluster; Cooperativity; Hodgkin-Huxley's model; Ion channels |
| المشرفين على المادة: | 0 (Ion Channels) |
| تواريخ الأحداث: | Date Created: 20240523 Date Completed: 20240609 Latest Revision: 20240609 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1016/j.bpc.2024.107257 |
| PMID: | 38781761 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4200 |
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| DOI: | 10.1016/j.bpc.2024.107257 |