دورية أكاديمية
Quantitative Abdominal Arterial Calcification Correlates with Kidney Transplant Waitlist Mortality.
| العنوان: | Quantitative Abdominal Arterial Calcification Correlates with Kidney Transplant Waitlist Mortality. |
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| المؤلفون: | Jarmi T; Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA., Hanouneh T; Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA, hanouneh.tareq@mayo.edu., Mao M; Division of General Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida, USA., Mao S; Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA., Young MC; Mayo Clinic Alex School of Medicine, Jacksonville, Florida, USA., Spaulding AC; Division of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic Florida, Jacksonville, Florida, USA., Sella DM; Department of Radiology, Mayo Clinic Florida, Jacksonville, Florida, USA., Alexander LF; Department of Radiology, Mayo Clinic Florida, Jacksonville, Florida, USA., Salehinejad H; Division of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic Florida, Jacksonville, Florida, USA., Craver EC; Department of Biostatistics, Mayo Clinic, Jacksonville, Florida, USA., Farres H; Division of Vascular Surgery, Mayo Clinic Florida, Jacksonville, Florida, USA. |
| المصدر: | Kidney & blood pressure research [Kidney Blood Press Res] 2024; Vol. 49 (1), pp. 397-405. Date of Electronic Publication: 2024 May 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 9610505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0143 (Electronic) Linking ISSN: 14204096 NLM ISO Abbreviation: Kidney Blood Press Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c1996- |
| مواضيع طبية MeSH: | Kidney Transplantation* , Waiting Lists*/mortality , Vascular Calcification*/mortality , Vascular Calcification*/diagnostic imaging, Humans ; Male ; Middle Aged ; Female ; Retrospective Studies ; Adult ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/complications ; Aged ; Tomography, X-Ray Computed ; Aorta, Abdominal/diagnostic imaging |
| مستخلص: | Introduction: The scarcity of available organs for kidney transplantation has resulted in a substantial waiting time for patients with end-stage kidney disease. This prolonged wait contributes to an increased risk of cardiovascular mortality. Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases, and it is common among candidates for kidney transplant. The aim of this study was to correlate abdominal arterial calcification (AAC) score value with mortality on the waitlist. Methods: We modified the coronary calcium score and used it to quantitate the AAC. We conducted a retrospective clinical study of all adult patients who were listed for kidney transplant, between 2005 and 2015, and had abdominal computed tomography scan. Patients were divided into two groups: those who died on the waiting list group and those who survived on the waiting list group. Results: Each 1,000 increase in the AAC score value of the sum score of the abdominal aorta, bilateral common iliac, bilateral external iliac, and bilateral internal iliac was associated with increased risk of death (HR 1.034, 95% CI: 1.013, 1.055) (p = 0.001). This association remained significant even after adjusting for various patient characteristics, including age, tobacco use, diabetes, coronary artery disease, and dialysis status. Conclusion: The study highlights the potential value of the AAC score as a noninvasive imaging biomarker for kidney transplant waitlist patients. Incorporating the AAC scoring system into routine imaging reports could facilitate improved risk assessment and personalized care for kidney transplant candidates. (© 2024 The Author(s). Published by S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Abdominal arterial calcification; End-stage kidney disease; Kidney transplant; Mortality; Waitlist |
| تواريخ الأحداث: | Date Created: 20240523 Date Completed: 20240617 Latest Revision: 20240617 |
| رمز التحديث: | 20240618 |
| DOI: | 10.1159/000539012 |
| PMID: | 38781937 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0143 |
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| DOI: | 10.1159/000539012 |