دورية أكاديمية
أعرض في EDS

Sex-Related Differences in the Phenotype and Course of Inflammatory Bowel Disease: SEXEII Study of ENEIDA.

التفاصيل البيبلوغرافية
العنوان: Sex-Related Differences in the Phenotype and Course of Inflammatory Bowel Disease: SEXEII Study of ENEIDA.
المؤلفون: Gargallo-Puyuelo CJ; Gastroenterology Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain; University of Zaragoza, School of Medicine, Zaragoza, Spain. Electronic address: carlajerusalen@hotmail.com., Ricart E; Gastroenterology Department, Hospital Clínic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en RED, Madrid, Spain., Iglesias E; Gastroenterology Department, Hospital Reina Sofía, Cordoba, Spain., de Francisco R; Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain., Gisbert JP; Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Universidad Autónoma de Madrid, Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas., Taxonera C; Gastroenterology Department, Hospital Clínico San Carlos, Instituto de Investigación del Hospital Clínico San Carlos, Madrid, Spain., Mañosa M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Universitat Autònoma de Barcelona., Aguas Peris M; Gastroenterology Department, Hospital Uniersitari i Politècnic La fe, València, Spain., Navarrete-Muñoz EM; Occupational Therapy Research Group, InTeO, Investigación en Terapia Ocupacional, Miguel Hernández University, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain., Sanahuja A; Gastroenterology Department, Hospital Universitario Clínico de Valencia, Valencia, Spain., Guardiola J; Gastroenterology Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain., Mesonero F; Gastroenterology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., Rivero Tirado M; Gastroenterology Department, Hospital Universitario Marqués de Valdecilla e IDIVAL, Santander, Spain., Barrio J; Gastroenterology Department, Hospital Rio Hortega, Valladolid, Spain., Vera Mendoza I; Gastroenterology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., de Castro Parga L; Gastroenterology Department, Hospital Álvaro Cunqueiro, Vigo, Spain., García-Planella E; Gastroenterolgy Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Calvet X; Gastroenterology Department, Hospital Universitario Parc Taulí, Sabadel, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas., Martín Arranz MD; Gastroenterology Department, La Paz Hospital Universitario, School of Medicine, Universidad Autónoma de Madrid, Hospital La Paz Institute for Health Research, La Paz Hospital, Madrid, Spain., García S; Gastroenterology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain, Instituto de Investigation Sanitaria de Aragón., Sicilia B; Gastroenterology Department, Hospital Universitario de Burgos, Burgos, Spain., Carpio D; Gastroenterology Department, Complexo Hospitalario de Pontevedra, Pontevedra, Spain., Domenech E; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Universitat Autònoma de Barcelona., Gomollón F; Gastroenterology Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain; University of Zaragoza, School of Medicine, Zaragoza, Spain.
مؤلفون مشاركون: ENEIDA registry of GETECCU
المصدر: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2024 May 22. Date of Electronic Publication: 2024 May 22.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders for the American Gastroenterological Association, 2003-
مستخلص: Background & Aims: The impact of patient sex on the presentation of inflammatory bowel disease (IBD) has been poorly evaluated. Our aims were to assess potential disparities in IBD phenotype and progression between sexes.
Methods: We performed an observational multicenter study that included patients with Crohn's disease (CD) or ulcerative colitis from the Spanish ENEIDA registry. Data extraction was conducted in July 2021.
Results: A total of 51,595 patients with IBD were included, 52% were males and 25,947 had CD. The median follow-up period after diagnosis was 9 years in males and 10 years in females. In CD, female sex was an independent risk factor for medium disease onset (age, 17-40 y) (relative risk ratio, 1.45; 95% CI, 1.31-1.62), later disease onset (age, >40 y) (relative risk ratio, 1.55; 95% CI, 1.38-1.73), exclusive colonic involvement (odds ratio, 1.24; 95% CI, 1.14-1.34), inflammatory behavior (odds ratio, 1.14; 95% CI, 1.07-1.21), and extraintestinal manifestations (odds ratio, 1.48; 95% CI, 1.38-1.59). However, female sex was a protective factor for upper gastrointestinal involvement (odds ratio, 0.84; 95% CI, 0.79-0.90), penetrating behavior (odds ratio, 0.76; 95% CI, 0.70-0.82), perianal disease (odds ratio, 0.77; 95% CI, 0.71-0.82), and complications (odds ratio, 0.73; 95% CI, 0.66-0.80). In ulcerative colitis, female sex was an independent risk factor for extraintestinal manifestations (odds ratio, 1.48; 95% CI, 1.26-1.61). However, female sex was an independent protective factor for disease onset from age 40 onward (relative risk ratio, 0.76; 95% CI, 0.66-0.87), left-sided colonic involvement (relative risk ratio, 0.72; 95% CI, 0.67-0.78), extensive colonic involvement (relative risk ratio, 0.59; 95% CI, 0.55-0.64), and abdominal surgery (odds ratio, 0.78; 95% CI, 0.69-0.88).
Conclusions: There is sexual dimorphism in IBD. The patient's sex should be taken into account in the clinical management of the disease.
(Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Investigator: L Márquez-Mosquera, Gastroenterology Department. Hospital del Mar, Barcelona. IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.; L Madero, Gastroenterology Department, Hospital General Universitario Dr Balmis e ISABIAL, Alicante. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; M Esteve, Gastroenterology Department, Hospital Universitari Mútua Terrassa. University of Barcelona. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; D Monfort, Gastroenterology department, Consorci Sanitari de Terrassa, Terrasa, Spain.; P Varela, Gastroenterology department, Hospital Universitario de Cabueñes, Gijón, Spain.; P Vega, Gastroenterology department, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.; GA Martínez, Gastroenterology department, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; I Rodriguez-Lago, Gastroenterology department, Hospital Universitario de Galdakao, Bizkaia, Spain. Biobizkaia Health Research Institute.; O García-Bosh, Gastroenterology Department, Hospital Moisès Broggi, Sant Joan Despí, Cataluña, Spain.; JL Pérez Calle, Gastroenterology department, Hospital Universitario Fundación de Alcorcón, Madrid, Spain.; O Merino, Gastroenterology department, Hospital Universitario de Cruces, Barakaldo, Spain.; M Sierra Ausin, Gastroenterology department, Complejo Asistencial Universitario de León, León, Spain.; C Tardillo, Gastroenterology Department, Hospital Universitario Nuestra Sra. de la Candelaria, Santa Cruz de Tenerife, Spain.; R Lorente Poyatos, Gastroenterology department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.; LI Fernandez-Salazar, Gastroenterology department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.; MF García Sepulcre, Gastroenterology department, Hospital General Universitario de Elche, Alicante, Spain.; F Bermejo, Gastroenterology department, Hospital Universitario de Fuenlabrada, Madrid, Spain.; NM Arce, Gastroenterology department, Hospital de Manises, Valencia, Spain.; L Bujanda, Department of Hepatology and Gastroenterology, Bioodonostia Health Research Institute - Donostia University Hospital, Universidad del País Vasco (UPV/EHU), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), San Sebastián, Spain.; J Riera, Gastroenterology department, Hospital Universitario Son Llàtzer, Manacor, Spain.; Y Ber, Gastroenterology department, Hospital General San Jorge, Huesca, Spain.; Á Ponferrada Díaz, Gastroenterology department, Hospital Universitario Infanta Leonor, Madrid, Spain.; F BasCutrina, Gastroenterology department, Hospital General de Granollers, Cataluña, Spain.; P Martinez Montiel, Gastroenterology department, Hospital Universitario Doce de Octubre, Madrid, Spain.; L Ramos, Gastroenterology department, Hospital Universitario de Canarias, La Laguna, Spain.; J Llaó, Gastroenterology department, Althaia Xarxa Assistencial Universitària de Manresa, Cataluña, Spain.; M Barreiro-de Acosta, Gastroenterology department, Hospital Clínico Universitario de Santiago - CHUS, Spain.; C Rodriguez Gutierrez, Gastroenterology department, Complejo Hospitalario de Navarra, Pamplona, Spain.; F Muñoz, Gastroenterology department, Hospital Universitario de Salamanca, Salamanca, Spain.; E Sese, Gastroenterology department, Hospital Universitario Arnau de Vilanova, Lleida, Spain.; R Blat, Gastroenterology Department, Hospital Dr. Josep Trueta, Girona, Spain.; JM Huguet, Gastroenterology department, Hospital General Universitario de Valencia, Valencia, Spain.; I Marín-Jiménez, Gastroenterology Department, IiSGM, Hospital Gregorio Marañón; Medicine Faculty, Complutense University, Madrid, Spain.; C Martínez-Flores, Gastroenterology Department, Hospital General La Mancha Centro, Alcázar de San Juan.; M Van Domselaar, Gastroenterology Department, Hospital Universitario de Torrejón. Universidad Francisco de Vitoria, Torrejón de Ardoz, Spain.; AJ Lucendo, Gastroenterology department, Hospital Público General de Tomelloso, Spain. Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM). Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD).; D Ginard, Gastroenterology Department, Hospital Son Espases, Palma de Mallorca.; M Menacho, Gastroenterology department, Hospital Universitario Joan XXIII, Tarragona, Spain.; NM Marcos, Gastroenterology department, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Spain.; P Almela, Gastroenterology department, Hospital General Universitario de Castelló, Castellón de la Plana, Spain.; PR de la Piscina, Gastroenterology department, Hospital Universitario Áraba, Álava, Spain.; F Argüelles-Arias, Gastroenterology Department, H. Universitario Virgen Macarena. Facultad de Medicina, Universidad de Sevilla. Sevilla, Spain.; CM Vilafranca, Gastroenterology department, Hospital Universitario de Basurto, Bilbao, Spain.; E Peña, Gastroenterology department, Hospital Royo Villanova, Zaragoza, Spain.; PG Alvarez, Gastroenterology department, Hospital de Viladecans, Viladecans, Spain.; J Santos Fernández, Gastroenterology Department, Complejo Hospitalario de Palencia, Palencia, Spain.; AF Coronel, Gastroenterology Department, Complejo Asistencial de Zamora, Zamora, Spain.; L Hernández Villalba, Gastroenterology Department, Hospital Santos Reyes, Aranda del Duero, Spain.; PR Andres, Gastroenterology department, Hospital Universitario de Cáceres, Cáceres, Spain.; T Martínez Perez, Gastroenterology department, Hospital Virgen de la Luz, Cuenca, Spain.; J Legido Gil, Gastroenterology department, Complejo Asistencial de Segovia, Segovia, Spain.; H Fernandez, Gastroenterology department, Hospital San Pedro, Logroño, Spain.; E Castillo Regalado, Gastroenterology Department, Hospital Sant Jaume de Calella, Barcelona, Spain.; L Buendía, Gastroenterology department, Hospital Vega Baja, Orihuela, Spain.; AM Trapero Martinez, Gastroenterology department, Complejo Hospitalario de Jaén, Jaén, Spain.; C Leal, Gastroenterology Department, Consorci Hospitalari de Vic, Universitat de Vic-UCC, Barcelona, Spain.; EI Miyashiro, Gastroenterology Department, Hospital de Inca, Mallorca, Spain.; A García Herola, Gastroenterology Department, Hospital Marina Baixa, Villajoyosa, Spain.; S Frago, Gastroenterology Department, Hospital de Santa Bárbara, Soria, Spain.; MT Novella Duran, Gastroenterology Department, Hospital Ca Misses, Eivissa, Spain.; VM Navas López, Pediatric Gastroenterology & Nutrition Section. Hospital Regional Universitario de Málaga, Málaga, Spain.; IN de Prado, Gastroenterology department, Hospital General Universitario Reina Sofía de Murcia, Murcia, Spain.; P Bebia, Gastroenterology department, Hospital General Universitario Santa Lucia, Cartagena, Spain.; B Botella, Gastroenterology department, Hospital Universitario Infanta Cristina, Parla, Spain.; RA Muñoz, Gastroenterology department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Keywords: Clinical Course; Crohn’s Disease; Inflammatory Bowel Disease; Patient Sex; Phenotype; Ulcerative Colitis
تواريخ الأحداث: Date Created: 20240523 Latest Revision: 20240616
رمز التحديث: 20240617
DOI: 10.1016/j.cgh.2024.05.013
PMID: 38782172
قاعدة البيانات: MEDLINE
الوصف
تدمد:1542-7714
DOI:10.1016/j.cgh.2024.05.013